Oh, YM Sheen, SS Park, JH Jin, UR Yoo, JW Seo, JB Yoo, KH Lee, JH Kim, TH Lim, SY Yoon, HI Lee, JS Lee, SD 2016-04-15T07:28:20Z 2016-04-15T07:28:20Z 2014 1027-3719 http://repository.ajou.ac.kr/handle/201003/12380 SETTING: Frequent exacerbation is an important phenotype in chronic obstructive pulmonary disease (COPD), while emphysema is associated with many comorbidities and lung function decline. OBJECTIVE: To investigate unique features of frequent exacerbators and test the hypothesis that emphysematous phenotype is associated with frequent exacerbations of COPD. METHODS: A total of 380 COPD patients were recruited from 16 hospitals in Korea from June 2005 to April 2012 for analysis. We searched for independent predictors of frequent exacerbators in comparison with non-exacerbators. RESULTS: As the severity of emphysema increased, forced expiratory volume in 1 s (FEV(1)), and FEV(1)/FVC (forced volume capacity) worsened; hyperinflationary features characterised by higher total lung capacity (TLC) were observed (P < 0.05). Frequent exacerbators had lower body mass index (BMI), higher St George's Respiratory Questionnaire (SGRQ) scores, higher residual volume (RV)/TLC, more severe airflow limitation (lower FEV(1) and FEV(1)/FVC), lower carbon monoxide diffusion capacity, lower serum protein levels and a higher emphysema index than non-exacerbators (P < 0.05). In multivariate analysis, frequent exacerbators were independently associated with a higher emphysema index, lower serum protein levels and higher RV/TLC (P < 0.05). CONCLUSION: Our data show that the severity of emphysema, severe static hyperinflation and serum lower protein levels are independent predictors of frequent exacerbations in COPD patients. en Aged Biomarkers Blood Proteins Chi-Square Distribution Comorbidity Disease Progression Down-Regulation Female Forced Expiratory Volume Humans Logistic Models Lung Male Middle Aged Multivariate Analysis Odds Ratio Phenotype Predictive Value of Tests Prognosis Pulmonary Diffusing Capacity Pulmonary Disease, Chronic Obstructive Pulmonary Emphysema Republic of Korea Risk Factors Severity of Illness Index Surveys and Questionnaires Time Factors Total Lung Capacity Vital Capacity Emphysematous phenotype is an independent predictor for frequent exacerbation of COPD. Article 25517804 http://www.ingentaconnect.com/content/iuatld/ijtld/2014/00000018/00000012/art00006?token=005f1f1ed2ff9be1f86d1557e41225f4038382c2b465248773b777b6e576b3427656c3c6a333f2566b69c3c394f544b 신, 승수 박, 주헌 Journal Papers 10.5588/ijtld.14.0205 The international journal of tuberculosis and lung disease 18 12 2014 1407 1414 The international journal of tuberculosis and lung disease, 18(12). : 1407-1414, 2014 1815-7920 J010273719