Park, DJ Kim, SH Nah, SS Lee, JH Kim, SK Lee, YA Hong, SJ Kim, HS Lee, HS Kim, HA Joung, CI Kim, SH Lee, SS 2018-05-04T00:26:00Z 2018-05-04T00:26:00Z 2016 1462-0324 http://repository.ajou.ac.kr/handle/201003/15075 OBJECTIVE: Researchers continue to gather evidence that transient receptor potential vanilloid (TRPV) channels contribute towards pain signalling pathways. However, it is unknown whether polymorphisms of the TRPV gene are associated with FM. For the first time, we investigated the association between the polymorphisms of the TRPV2 and TRPV3 genes, FM susceptibility and the severity of the symptoms. METHODS: A total of 409 patients with FM and 423 controls were enrolled from 10 medical centres that participated in the Korean nationwide FM survey. The alleles and genotypes at three positions [rs3813768(C > G), rs8121(C > T) and rs1129235(C > A)] in the TRPV2 gene and two positions [rs7216486 (G > A) and rs395357(C > T)] in the TRPV3 gene were genotyped. RESULTS: The frequencies of the alleles and genotypes of individual TRPV2 and TRPV3 genes were not significantly associated with FM susceptibility. However, the GTA haplotype of TRPV2 showed a defence against FM susceptibility (P = 0.035). In addition, polymorphisms of TRPV3 were associated with symptom severity in FM patients. The single nucleotide polymorphism rs395357 of TRPV3 was associated with the scores of the Brief Fatigue Inventory (P = 0.017) in FM patients. Furthermore, haplotypes of TRPV3 were associated with the Brief Fatigue Inventory and the 36-item Short-Form Health Survey mental health summary scores (P = 0.036). CONCLUSION: This study was the first to evaluate the associations of TRPV gene polymorphisms with FM. Our results suggest that certain TRPV2 haplotypes may have a protective role against FM and that some genotypes and haplotypes of TRPV3 contribute towards the symptoms of FM. en Adult Case-Control Studies Cross-Sectional Studies Female Fibromyalgia Genetic Predisposition to Disease Genotype Haplotypes Humans Male Middle Aged Polymorphism, Genetic Polymorphism, Single Nucleotide Republic of Korea TRPV Cation Channels Polymorphisms of the TRPV2 and TRPV3 genes associated with fibromyalgia in a Korean population Article 27079220 김, 현아 Journal Papers 10.1093/rheumatology/kew180 Rheumatology (Oxford, England) 55 8 2016 1518 1527 Rheumatology (Oxford, England), 55(8). : 1518-1527, 2016 9999-12-31 9999-12-31 1462-0332 J014620324