Moon, SY Park, YK Jeong, JH Hong, CH Jung, J Na, HR Cho, SH Kim, HS Song, HS Choi, M Ku, BD Moon, YS Han, HJ Hong, YJ Kim, EJ Kim, GH Kim, KW Jang, H Yoon, SJ Kim, HJ Choi, SH 2025-04-21T01:02:02Z 2025-04-21T01:02:02Z 2025 1552-5260 http://repository.ajou.ac.kr/handle/201003/34049 INTRODUCTION: We investigated the efficacy of a multidomain intervention (MI) via face-to-face and video communication platforms using a tablet personal computer application in patients with mild cognitive impairment (MCI). METHODS: Three hundred participants with MCI and >/= 1 modifiable dementia risk factor, aged 60-85 years, were randomly assigned to either the MI group, who underwent a 24-week intervention, or the control group, who received usual care. RESULTS: The overall adherence rate to MI was 84.7%. The adjusted mean change from baseline at 24 weeks in the total scale index score of the repeatable battery for the assessment of neuropsychological status was 8.43 in the MI group and 4.26 in the control group (difference, 4.17; 95% confidence interval, 1.92-6.43; p < 0.001). MI showed significant beneficial effects on cognition in both apolipoprotein E (APOE) epsilon4 carriers and noncarriers. DISCUSSION: MI can exert beneficial effects on the cognition of patients with MCI. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT05023057 HIGHLIGHTS: Although the controls also demonstrated improved performance in cognition, multidomain interventions showed significantly greater benefits for cognition in MCI compared to the controls in a randomized controlled trial. Multidomain interventions improved depression and quality of life. Multidomain interventions significantly positively impacted cognition in both APOE epsilon4 carriers and noncarriers. Multidomain interventions may be more effective for amnestic than nonamnestic MCI. en Aged Aged, 80 and over Apolipoprotein E4 Cognitive Dysfunction Female Humans Male Middle Aged Neuropsychological Tests Republic of Korea Treatment Outcome South Korean study to prevent cognitive impairment and protect brain health through multidomain interventions via face-to-face and video communication platforms in mild cognitive impairment (SUPERBRAIN-MEET): A randomized controlled trial Article 39840755 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848216 cognition dementia exercise lifestyle mild cognitive impairment prevention randomized controlled trial Moon, SY Hong, CH Journal Papers 10.1002/alz.14517 Alzheimer's & dementia 21 2 2025 e14517 e14517 Alzheimer's & dementia, 21(2). : e14517-e14517, 2025 1552-5279 J015525260