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Echocardiographically measured epicardial fat predicts restenosis after coronary stenting.

Authors
Park, JS; Choi, BJ; Choi, SY; Yoon, MH; Hwang, GS; Tahk, SJ; Shin, JH
Citation
Scandinavian cardiovascular journal : SCJ, 47(5):297-302, 2013
Journal Title
Scandinavian cardiovascular journal : SCJ
ISSN
1401-74311651-2006
Abstract
OBJECTIVE: Epicardial adipose tissue (EAT), deposited around subepicardial coronary vessels, may contribute directly to perivascular inflammation and smooth muscle cell proliferation. This study assessed the relationship between EAT and in-stent restenosis.



METHODS: Four hundred and seven patients had received successful coronary intervention. EAT thickness was measured by echocardiography. Angiographic follow-up was obtained between 6 months and 2 years. Restenosis was defined as target lesion revascularization (TLR). EAT thickness of patients was compared by TLR controlling for additional well-known predictors of restenosis. The TLR-free survival analysis according to EAT thickness was estimated using the Kaplan-Meier method and the differences between groups were assessed by the log-rank test.



RESULTS: Median EAT thickness was significantly increased in patients undergoing TLR compared with those without restenosis (3.7 vs. 3.0 mm, p = 0.001). EAT thickness was one of the independent factors associated with restenosis (Odds ratio = 1.19, 95% confidence interval = 1.01-1.33, p = 0.007). The TLR-free survival of patients with thick EAT was significantly worse than patients with thin EAT (log-rank p = 0.001).



CONCLUSIONS: EAT thickness is related with restenosis and may provide additional information for future restenosis.
MeSH terms
Adipose Tissue/*ultrasonography*AdiposityAgedCoronary Restenosis/*etiologyEchocardiographyFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedPercutaneous Coronary InterventionPostoperative Complications/etiology/ultrasonographyStents/adverse effects
DOI
10.3109/14017431.2013.824604
PMID
23937273
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
AJOU Authors
박, 진선최, 병주최, 소연윤, 명호황, 교승탁, 승제신, 준한
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