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In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography.

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dc.contributor.authorJia, H-
dc.contributor.authorAbtahian, F-
dc.contributor.authorAguirre, AD-
dc.contributor.authorLee, S-
dc.contributor.authorChia, S-
dc.contributor.authorLowe, H-
dc.contributor.authorKato, K-
dc.contributor.authorYonetsu, T-
dc.contributor.authorVergallo, R-
dc.contributor.authorHu, S-
dc.contributor.authorTian, J-
dc.contributor.authorLee, H-
dc.contributor.authorPark, SJ-
dc.contributor.authorJang, YS-
dc.contributor.authorRaffel, OC-
dc.contributor.authorMizuno, K-
dc.contributor.authorUemura, S-
dc.contributor.authorItoh, T-
dc.contributor.authorKakuta, T-
dc.contributor.authorChoi, SY-
dc.contributor.authorDauerman, HL-
dc.contributor.authorPrasad, A-
dc.contributor.authorToma, C-
dc.contributor.authorMcNulty, I-
dc.contributor.authorZhang, S-
dc.contributor.authorYu, B-
dc.contributor.authorFuster, V-
dc.contributor.authorNarula, J-
dc.contributor.authorVirmani, R-
dc.contributor.authorJang, IK-
dc.date.accessioned2014-05-19T05:52:08Z-
dc.date.available2014-05-19T05:52:08Z-
dc.date.issued2013-
dc.identifier.issn0735-1097-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/10006-
dc.description.abstractOBJECTIVES: The aim of this study was to characterize the morphological features of plaque erosion and calcified nodule in patients with acute coronary syndrome (ACS) by optical coherence tomography (OCT).



BACKGROUND: Plaque erosion and calcified nodule have not been systematically investigated in vivo.



METHODS: A total of 126 patients with ACS who had undergone pre-intervention OCT imaging were included. The culprit lesions were classified as plaque rupture (PR), erosion (OCT-erosion), calcified nodule (OCT-CN), or with a new set of diagnostic criteria for OCT.



RESULTS: The incidences of PR, OCT-erosion, and OCT-CN were 43.7%, 31.0%, and 7.9%, respectively. Patients with OCT-erosion were the youngest, compared with those with PR and OCT-CN (53.8 ± 13.1 years vs. 60.6 ± 11.5 years, 65.1 ± 5.0 years, p = 0.005). Compared with patients with PR, presentation with non-ST-segment elevation ACS was more common in patients with OCT-erosion (61.5% vs. 29.1%, p = 0.008) and OCT-CN (100% vs. 29.1%, p < 0.001). The OCT-erosion had a lower frequency of lipid plaque (43.6% vs. 100%, p < 0.001), thicker fibrous cap (169.3 ± 99.1 μm vs. 60.4 ± 16.6 μm, p < 0.001), and smaller lipid arc (202.8 ± 73.6° vs. 275.8 ± 60.4°, p < 0.001) than PR. The diameter stenosis was least severe in OCT-erosion, followed by OCT-CN and PR (55.4 ± 14.7% vs. 66.1 ± 13.5% vs. 68.8 ± 12.9%, p < 0.001).



CONCLUSIONS: Optical coherence tomography is a promising modality for identifying OCT-erosion and OCT-CN in vivo. The OCT-erosion is a frequent finding in patients with ACS, especially in those with non-ST-segment elevation ACS and younger patients. The OCT-CN is the least common etiology for ACS and is more common in older patients. (The Massachusetts General Hospital Optical Coherence Tomography Registry; NCT01110538).
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dc.language.isoen-
dc.subject.MESHAcute Coronary Syndrome-
dc.subject.MESHAged-
dc.subject.MESHCalcinosis-
dc.subject.MESHCoronary Angiography-
dc.subject.MESHCoronary Vessels-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPlaque, Atherosclerotic-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHTomography, Optical Coherence-
dc.subject.MESHWorld Health-
dc.titleIn vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography.-
dc.typeArticle-
dc.identifier.pmid23810884-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874870/-
dc.contributor.affiliatedAuthor최, 소연-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.jacc.2013.05.071-
dc.citation.titleJournal of the American College of Cardiology-
dc.citation.volume62-
dc.citation.number19-
dc.citation.date2013-
dc.citation.startPage1748-
dc.citation.endPage1758-
dc.identifier.bibliographicCitationJournal of the American College of Cardiology, 62(19). : 1748-1758, 2013-
dc.identifier.eissn1558-3597-
dc.relation.journalidJ007351097-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
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