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Injectable extracellular matrix hydrogel developed using porcine articular cartilage.

Authors
Kwon, JS; Yoon, SM; Shim, SW; Park, JH; Min, KJ; Oh, HJ; Kim, JH; Kim, YJ; Yoon, JJ; Choi, BH; Kim, MS
Citation
International journal of pharmaceutics, 454(1):183-191, 2013
Journal Title
International journal of pharmaceutics
ISSN
0378-51731873-3476
Abstract
This work was first development of a delivery system capable of maintaining a sustained release of protein drugs at specific sites by using potentially biocompatible porcine articular cartilage. The prepared porcine articular cartilage powder (PCP) was easily soluble in phosphate-buffered saline. The PCP suspension easily entrapped bovine serum albumin-fluorescein isothiocyanate (BSA-FITC) in pharmaceutical formulations at room temperature. The aggregation of PCP and BSA-FITC was confirmed by dynamic light scattering. When the BSA-FITC-loaded PCP suspension was subcutaneously injected into rats, it gelled and formed an interconnecting three-dimensional PCP structure that allowed BSA to penetrate through it. The amount of BSA-FITC released from the PCP hydrogel was determined in rat plasma and monitored by real-time in vivo molecular imaging. The data indicated sustained release of BSA-FITC for 20 days in vivo. In addition, the PCP hydrogel induced a slight inflammatory response. In conclusion, we showed that the PCP hydrogel could serve as a minimally invasive therapeutics depot.
MeSH terms
AnimalsBiocompatible Materials/administration & dosage/*chemistry/toxicityCartilage, Articular/*chemistryDelayed-Action Preparations*Drug CarriersExtracellular Matrix/*chemistryFluorescein-5-isothiocyanate/administration & dosage/analogs & derivatives/chemistryHydrogelsInflammation/chemically inducedInjections, SubcutaneousLightPowdersRatsRats, Sprague-DawleyScattering, RadiationSerum Albumin, Bovine/administration & dosage/chemistrySolubilityTechnology, Pharmaceutical/methodsTemperatureTime FactorsViscosity
DOI
10.1016/j.ijpharm.2013.06.023
PMID
23834831
Appears in Collections:
Journal Papers > Research Organization > Cell Therapy Center
AJOU Authors
김, 영직
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