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Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism.

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dc.contributor.authorKemper, JK-
dc.contributor.authorChoi, SE-
dc.contributor.authorKim, DH-
dc.date.accessioned2014-05-20T06:27:27Z-
dc.date.available2014-05-20T06:27:27Z-
dc.date.issued2013-
dc.identifier.issn0083-6729-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/10022-
dc.description.abstractObesity is a serious medical problem worldwide and disruption of metabolic/energy homeostasis plays a pivotal role in this global epidemic. In obese people, fatty liver (steatosis) develops, which increases the risk for diabetes, cardiovascular disease, and even, liver cancer. Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase that functions as a key metabolic/energy sensor and mediates homeostatic responses to nutrient availability. Accumulating evidence indicates that SIRT1 is a master regulator of the transcriptional networks that control hepatic lipid metabolism. During energy-deprived conditions, SIRT1 deacetylates and alters the expression and activities of key transcriptional regulators involved in hepatic lipogenesis, fatty acid β-oxidation, and cholesterol/bile acid metabolism. This review will discuss the latest advances in this field, focusing on beneficial roles of SIRT1 in hepatic lipid metabolism including its potential as a therapeutic target for treatment of steatosis and other obesity-related metabolic diseases.-
dc.language.isoen-
dc.subject.MESHHumans-
dc.subject.MESHLipid Metabolism-
dc.subject.MESHLiver-
dc.subject.MESHObesity-
dc.subject.MESHSirtuin 1-
dc.titleSirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism.-
dc.typeArticle-
dc.identifier.pmid23374725-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976444/-
dc.contributor.affiliatedAuthor최, 성이-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/B978-0-12-407766-9.00016-X-
dc.citation.titleVitamins and hormones-
dc.citation.volume91-
dc.citation.date2013-
dc.citation.startPage385-
dc.citation.endPage404-
dc.identifier.bibliographicCitationVitamins and hormones, 91. : 385-404, 2013-
dc.relation.journalidJ000836729-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
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