72 208

Cited 4 times in

Association between the SPRY1 gene polymorphism and obesity-related traits and osteoporosis in Korean women.

Authors
Jin, HS; Kim, BY; Kim, J; Hong, KW; Jung, SY; Lee, YS; Huh, D; Oh, B; Chung, YS; Jeong, SY
Citation
Molecular genetics and metabolism, 108(1):95-101, 2013
Journal Title
Molecular genetics and metabolism
ISSN
1096-71921096-7206
Abstract
BACKGROUND: Emerging evidence has revealed a close relationship between obesity and osteoporosis. It was reported recently that conditional knockout of the Spry1 gene in mice adipocytes causes an increase in body fat and a decrease in bone mass, and that these phenotypes are rescued by Spry1 overexpression in adipose tissue. In this study, we investigated whether genetic variation in the human SPRY1 gene is associated with obesity-related phenotypes and/or osteoporosis in humans.



METHODS: We performed a candidate gene association analysis between the four single nucleotide polymorphisms (SNPs) and 14 imputed SNPs in the SPRY1 gene and obesity-related traits and osteoporosis in a Korean women cohort (3013 subjects).



RESULTS: All four SPRY1 gene SNPs were significantly associated with either obesity-related traits or osteoporosis. The TGCC haplotype in the SRPY1 gene showed simultaneous association with an increased risk for obesity-related traits, percentage body fat (p=0.0087) and percentage abdominal fat (p=0.047), and osteoporosis (odds ratio=1.50; p=0.025) in the recessive genetic model.



CONCLUSIONS: Our results support a previous finding in conditional Spry1 gene knockout mice and suggest that the SPRY1 gene is an important genetic factor for determining the risk of both obesity and osteoporosis in humans.
MeSH terms
AdultAgedFemaleHumansMaleMembrane Proteins/*geneticsMiddle AgedObesity/complications/*geneticsOsteoporosis/complications/*genetics/physiopathologyPhosphoproteins/*genetics*Polymorphism, GeneticRepublic of Korea
DOI
10.1016/j.ymgme.2012.10.017
PMID
23146288
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Genetics
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
진, 현석김, 보영정, 윤석정, 선용
Full Text Link
Files in This Item:
fulltext not available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse