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Implication of circulating omentin-1 level on the arterial stiffening in type 2 diabetes mellitus.

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dc.contributor.authorYoo, HJ-
dc.contributor.authorHwang, SY-
dc.contributor.authorHong, HC-
dc.contributor.authorChoi, HY-
dc.contributor.authorYang, SJ-
dc.contributor.authorLee, KW-
dc.contributor.authorNam, MS-
dc.contributor.authorPark, YS-
dc.contributor.authorWoo, JT-
dc.contributor.authorKim, YS-
dc.contributor.authorChoi, KM-
dc.contributor.authorBaik, SH-
dc.date.accessioned2014-05-21T01:09:12Z-
dc.date.available2014-05-21T01:09:12Z-
dc.date.issued2013-
dc.identifier.issn1355-008X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/10042-
dc.description.abstractOmentin-1 is an adipokine implicated in diabetes, inflammation, and cardiovascular disease. However, no prospective studies have examined the impact of circulating omentin-1 levels on arterial stiffening in patients with type 2 diabetes mellitus. For the purpose of this study, we recruited 120 patients with type 2 diabetes mellitus and measured serum omentin-1, adiponectin, and high-sensitivity C-reactive protein levels as well as other cardiovascular risk factors. Arterial stiffness was assessed by brachial ankle pulse wave velocity (baPWV). An increase in the level of circulating omentin-1 over a period of 1 year was positively correlated with changes in levels of HbA1c and serum adiponectin as well as baPWV. Subjects with higher baseline serum omentin-1 levels tended to have a reduced arterial stiffness after 1 year (P for linear trend = 0.03). In the group with increased baPWV after 1 year, the magnitude of increase of circulating omentin-1 levels was significantly higher than in the group with a lower baPWV after 1 year (134.3 [16.6, 277.1] ng/mL vs. 15.9 [-67.6, 145.7] ng/mL, P < 0.01). Multiple stepwise logistic regression analysis revealed that an increase in systolic blood pressure and an increase in serum omentin-1 level were independently correlated with arterial stiffening, even after adjusting for other cardiovascular risk factors and medication history. Baseline serum omentin-1 levels can predict arterial stiffness changes occurring within a year. Furthermore, changes in serum omentin-1 levels after a year can function as independent markers of arterial stiffening in patients with type 2 diabetes mellitus.-
dc.language.isoen-
dc.titleImplication of circulating omentin-1 level on the arterial stiffening in type 2 diabetes mellitus.-
dc.typeArticle-
dc.identifier.pmid23532633-
dc.contributor.affiliatedAuthor이, 관우-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s12020-013-9930-1-
dc.citation.titleEndocrine-
dc.citation.volume44-
dc.citation.number3-
dc.citation.date2013-
dc.citation.startPage680-
dc.citation.endPage687-
dc.identifier.bibliographicCitationEndocrine, 44(3). : 680-687, 2013-
dc.identifier.eissn1559-0100-
dc.relation.journalidJ01355008X-
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Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
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