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Role of CXCR2 on the immune modulating activity of α-iso-cubebenol a natural compound isolated from the Schisandra chinensis fruit.

Authors
Jung, YS; Lee, SK; Ok, CY; Cho, EJ; Park, JS; Choi, YW; Bae, YS
Citation
Biochemical and biophysical research communications, 431(3):433-436, 2013
Journal Title
Biochemical and biophysical research communications
ISSN
0006-291X1090-2104
Abstract
Previously, we demonstrated that α-iso-cubebenol, a natural compound isolated from the fruits of Schisandra chinensis, strongly enhances therapeutic efficacy against cecal ligation and puncture challenge-induced sepsis. In this study, we found that α-iso-cubebenol stimulated calcium increase and degranulation in human neutrophils. α-Iso-cubebenol also strongly induced neutrophil chemotaxis, which was completely blocked by a CXCR2 antagonist, SB225002. The increased survival rate by α-iso-cubebenol was also significantly attenuated by SB225002. Taken together, the results indicate that α-iso-cubebenol-induced anti-septic activity was mediated by CXCR2, suggesting CXCR2 as an important target for the regulation of sepsis and inflammation.
MeSH terms
AnimalsCalcium/metabolismCell Degranulation/drug effects/immunologyChemotaxis/drug effects/immunologyHumansImmunologic Factors/isolation & purification/*pharmacology/therapeutic useMaleMiceMice, Inbred ICRNeutrophils/drug effects/immunologyPhenylurea Compounds/pharmacologyReceptors, Interleukin-8B/antagonists & inhibitors/*physiologySchisandra/*chemistrySepsis/*drug therapy/immunologySesquiterpenes/isolation & purification/*pharmacology/therapeutic use
DOI
10.1016/j.bbrc.2012.12.152
PMID
23333379
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
AJOU Authors
박, 준성
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