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5-Fluorouracil, mitomycin-c, and polysaccharide-k versus uracil-ftorafur and polysaccharide-K as adjuvant chemoimmunotherapy for patients with locally advanced gastric cancer with curative resection.

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dc.contributor.authorAhn, MS-
dc.contributor.authorKang, SY-
dc.contributor.authorLee, HW-
dc.contributor.authorJeong, SH-
dc.contributor.authorPark, JS-
dc.contributor.authorLee, KJ-
dc.contributor.authorCho, YK-
dc.contributor.authorHan, SU-
dc.contributor.authorLee, SY-
dc.contributor.authorLim, HY-
dc.contributor.authorChoi, JH-
dc.date.accessioned2014-05-21T01:56:31Z-
dc.date.available2014-05-21T01:56:31Z-
dc.date.issued2013-
dc.identifier.issn0378-584X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/10051-
dc.description.abstractBACKGROUND: Despite the small but significant survival benefit of adjuvant chemotherapy in locally advanced gastric cancer (LAGC), the optimal regimen remains to be determined. We conducted a randomized trial comparing oral (PO) chemoimmunotherapy (CITX) with intravenous (IV) CITX in LAGC patients (stages IB-IIIB) with curative resection (≥ D2 dissection).



METHODS: The patients were randomized to the IV (5-fluorouracil 500 mg/m(2) weekly for 24 weeks, mitomycin-C 8 mg/m(2) every 6 weeks × 4) or the PO (uracil-ftorafur (UFT) 400-600 mg/day for 12 months) group. Patients in both groups received PO polysaccharide-K (3 g/day for 4 months). The planned number of patients was 368 for proving the non-inferiority of PO CITX compared to IV CITX for overall survival.



RESULTS: The trial was closed prematurely after enrolling 82 patients (44 in the IV group, 38 in the PO group). With a median follow-up of 82 months, there were no significant differences in the 5-year disease-free survival (73% vs. 55%, p = 0.358) and overall survival (77% vs. 66%, p = 0.159) between the 2 groups. The IV group demonstrated a higher incidence of grade 2 or 3 neutropenia, thrombocytopenia, and vomiting.



CONCLUSIONS: PO CITX with UFT appeared to be at least non-inferior to 5-fluorouracil and mitomycin-C CITX, with lower toxicity in the adjuvant treatment for LAGC.
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dc.formattext/plain-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHFluorouracil-
dc.subject.MESHHumans-
dc.subject.MESHImmunotherapy-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMitomycin-
dc.subject.MESHPrevalence-
dc.subject.MESHProteoglycans-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.subject.MESHStomach Neoplasms-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTegafur-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUracil-
dc.title5-Fluorouracil, mitomycin-c, and polysaccharide-k versus uracil-ftorafur and polysaccharide-K as adjuvant chemoimmunotherapy for patients with locally advanced gastric cancer with curative resection.-
dc.typeArticle-
dc.identifier.pmid23921761-
dc.identifier.urlhttp://www.karger.com/?DOI=10.1159/000349957-
dc.contributor.affiliatedAuthor안, 미선-
dc.contributor.affiliatedAuthor강, 석윤-
dc.contributor.affiliatedAuthor이, 현우-
dc.contributor.affiliatedAuthor정, 성현-
dc.contributor.affiliatedAuthor박, 준성-
dc.contributor.affiliatedAuthor이, 광재-
dc.contributor.affiliatedAuthor조, 용관-
dc.contributor.affiliatedAuthor한, 상욱-
dc.contributor.affiliatedAuthor이, 순영-
dc.contributor.affiliatedAuthor최, 진혁-
dc.type.localJournal Papers-
dc.identifier.doi10.1159/000349957-
dc.citation.titleOnkologie-
dc.citation.volume36-
dc.citation.number7-8-
dc.citation.date2013-
dc.citation.startPage421-
dc.citation.endPage426-
dc.identifier.bibliographicCitationOnkologie, 36(7-8). : 421-426, 2013-
dc.identifier.eissn1423-0240-
dc.relation.journalidJ00378584X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
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