88 292

Cited 86 times in

Identification of asthma clusters in two independent Korean adult asthma cohorts.

DC Field Value Language
dc.contributor.authorKim, TB-
dc.contributor.authorJang, AS-
dc.contributor.authorKwon, HS-
dc.contributor.authorPark, JS-
dc.contributor.authorChang, YS-
dc.contributor.authorCho, SH-
dc.contributor.authorChoi, BW-
dc.contributor.authorPark, JW-
dc.contributor.authorNam, DH-
dc.contributor.authorYoon, HJ-
dc.contributor.authorCho, YJ-
dc.contributor.authorMoon, HB-
dc.contributor.authorCho, YS-
dc.contributor.authorPark, CS-
dc.contributor.authorCOREA Study Group-
dc.date.accessioned2014-05-22T04:40:54Z-
dc.date.available2014-05-22T04:40:54Z-
dc.date.issued2013-
dc.identifier.issn0903-1936-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/10065-
dc.description.abstractAsthma is a heterogeneous airway disease with various clinical phenotypes. It is crucial to clearly identify clinical phenotypes to achieve better asthma management. We used cluster analysis to classify the clinical groups of 724 asthmatic patients from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA), and in 1843 subjects from another independent Korean asthma cohort of Soonchunhyang University Asthma Genome Research Centre (SCH) (Bucheon, Republic of Korea). Hierarchical cluster analysis was performed by Ward's method, followed by κ-means cluster analysis. Cluster analysis of the COREA cohort indicated four asthma subtypes: 1) smoking asthma; 2) severe obstructive asthma; 3) early-onset atopic asthma; and 4) late-onset mild asthma. An independent cluster analysis of the SCH cohort also indicated four clusters that were similar to the COREA clusters. Our results indicate that adult Korean asthma patients can be classified into four distinct clusters.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAge of Onset-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHAsthma/*diagnosis/ethnology/*therapy-
dc.subject.MESHBody Mass Index-
dc.subject.MESHCluster Analysis-
dc.subject.MESHCohort Studies-
dc.subject.MESHFemale-
dc.subject.MESHForced Expiratory Volume-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPhenotype-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSmoking-
dc.subject.MESHYoung Adult-
dc.titleIdentification of asthma clusters in two independent Korean adult asthma cohorts.-
dc.typeArticle-
dc.identifier.pmid23060627-
dc.identifier.urlhttp://erj.ersjournals.com/cgi/pmidlookup?view=long&pmid=23060627-
dc.contributor.affiliatedAuthor남, 동호-
dc.type.localJournal Papers-
dc.identifier.doi10.1183/09031936.00100811-
dc.citation.titleThe European respiratory journal-
dc.citation.volume41-
dc.citation.number6-
dc.citation.date2013-
dc.citation.startPage1308-
dc.citation.endPage1314-
dc.identifier.bibliographicCitationThe European respiratory journal, 41(6):1308-1314, 2013-
dc.identifier.eissn1399-3003-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse