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Case report of occupational asthma induced by polyvinyl chloride and nickel.

Authors
Song, GW; Ban, GY; Nam, YH; Park, HS; Ye, YM
Citation
Journal of Korean medical science, 28(10):1540-1542, 2013
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Polyvinyl chloride (PVC) is a widely used chemical for production of plastics. However occupational asthma (OA) caused by PVC has been reported only rarely. We report a 34-yr-old male wallpaper factory worker with OA due to PVC and nickel (Ni) whose job was mixing PVC with plasticizers. He visited the emergency room due to an asthma attack with moderate airflow obstruction and markedly increased sputum eosinophil numbers. A methacholine challenge test was positive (PC20 2.5 mg/mL). Bronchoprovocation tests with both PVC and Ni showed early and late asthmatic responses, respectively. Moreover, the fractional concentration of exhaled nitric oxide (FeNO) was increased after challenge with PVC. To our knowledge, this is the first case of OA in Korea induced by exposure to both PVC and Ni. We suggest that eosinophilic inflammation may be involved in the pathogenesis of PVC-induced OA and that FeNO monitoring can be used for its diagnosis.
MeSH terms
AdultAsthma, Occupational/*chemically induced/*diagnosisBreath TestsBronchial Provocation TestsEnvironmental ExposureEosinophilia/*diagnosisExhalationHumansLeukocyte CountMaleNickelNitric Oxide/metabolismOccupational ExposurePlasticizersPolyvinyl Chloride
DOI
10.3346/jkms.2013.28.10.1540
PMID
24133363
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
반, 가영박, 해심예, 영민
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