63 170

Cited 12 times in

Clinical significance of immunoglobulin E responses to staphylococcal superantigens in patients with aspirin-exacerbated respiratory disease.

DC Field Value Language
dc.contributor.authorYoo, HS-
dc.contributor.authorShin, YS-
dc.contributor.authorLiu, JN-
dc.contributor.authorKim, MA-
dc.contributor.authorPark, HS-
dc.date.accessioned2014-05-22T05:40:37Z-
dc.date.available2014-05-22T05:40:37Z-
dc.date.issued2013-
dc.identifier.issn1018-2438-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/10074-
dc.description.abstractBACKGROUND: Previous studies have reported a higher prevalence of immunoglobulin E (IgE) specific for staphylococcal superantigens (SAg) in the nasal mucosa of patients with aspirin-exacerbated respiratory disease (AERD), associated with eosinophilic inflammation and leukotriene production. However, the role of SAg-specific IgE in the pathogenesis of AERD is not well understood. We evaluated the clinical significance of serum IgE specific for three types of SAg, namely staphylococcal enterotoxins A and B (SEA and SEB) and toxic shock syndrome toxin-1 (TSST-1) in AERD.



METHODS: We enrolled 147 patients with AERD confirmed by a lysine-acetyl salicylic acid bronchoprovocative test and compared them with 147 patients with aspirin-tolerant asthma (ATA) and 141 healthy controls (NC). The levels of serum total IgE and SAg-specific IgE were measured using an ImmunoCAP system. Other clinical parameters were analyzed retrospectively.



RESULTS: The prevalences of SEA-, SEB- and TSST-1-specific IgE in the AERD and ATA groups were significantly higher than those in the NC group (p < 0.05, respectively). The total IgE level was significantly higher in patients with AERD with high levels of SEA-specific IgE than in those with lower levels (p < 0.05), with significant positive correlations between total and SAE-specific IgE levels (p < 0.05). The PC20 methacholine level was significantly lower in patients with AERD with high levels of SEA-specific IgE, while a significantly higher eosinophil count was noted in patients with AERD with high levels of SEB-specific IgE (p < 0.05, respectively).



CONCLUSIONS: Specific IgE responses to SAg may increase the serum total IgE level, airway hyperresponsiveness and eosinophil activation, leading to more severe clinical symptoms in AERD.
-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAntibody Specificity-
dc.subject.MESHAsthma, Aspirin-Induced/*immunology-
dc.subject.MESHBacterial Toxins/*immunology-
dc.subject.MESHEnterotoxins/*immunology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin E/*blood-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHSuperantigens/classification/*immunology-
dc.titleClinical significance of immunoglobulin E responses to staphylococcal superantigens in patients with aspirin-exacerbated respiratory disease.-
dc.typeArticle-
dc.identifier.pmid24193355-
dc.identifier.urlhttp://www.karger.com/?DOI=10.1159/000353976-
dc.contributor.affiliatedAuthor유, 혜수-
dc.contributor.affiliatedAuthor신, 유섭-
dc.contributor.affiliatedAuthor김, 미애-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.identifier.doi10.1159/000353976-
dc.citation.titleInternational archives of allergy and immunology-
dc.citation.volume162-
dc.citation.number4-
dc.citation.date2013-
dc.citation.startPage340-
dc.citation.endPage345-
dc.identifier.bibliographicCitationInternational archives of allergy and immunology, 162(4):340-345, 2013-
dc.identifier.eissn1423-0097-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Files in This Item:
fulltext not available.txtDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse