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Comparison of specific IgE antibodies to wheat component allergens in two phenotypes of wheat allergy.

Authors
Nam, YH; Hwang, EK; Jin, HJ; Lee, JM; Shin, YS; Ye, YM; Palacin, A; Salcedo, G; Lee, SY; Park, HS
Citation
Journal of Korean medical science, 28(11):1697-1699, 2013
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Specific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were wheat-induced anaphylaxis and/or urticaria (n=21, group I) and baker's asthma (n=8, group II) were enrolled. The prevalence of serum specific IgE to Tri a 14 was higher in group II (25%) than in group I (4.8%), while the serum specific IgE to gliadin was significantly higher in group I (70%) than in group II (12.5%). The cutoff value for predicting the baker's asthma using the ratio of serum specific IgE to Tri a 14 to gliadin was 742.8 optical density×1,000/(kU/L) with high sensitivity and specificity. These findings suggest that Tri a 14/gliadin may be a potential marker for predicting baker's asthma.
Keywords
Baker's AsthmaGliadinLipid Transfer ProteinWheat
DOI
10.3346/jkms.2013.28.11.1697
PMID
24265539
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
이, 정민신, 유섭예, 영민이, 수영박, 해심
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