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Can early B-type natriuretic peptide assays predict symptomatic patent ductus arteriosus in extremely low birth weight infants?

DC Field Value Language
dc.contributor.authorLee, JH-
dc.contributor.authorShin, JH-
dc.contributor.authorPark, KH-
dc.contributor.authorRhie, YJ-
dc.contributor.authorPark, MS-
dc.contributor.authorChoi, BM-
dc.date.accessioned2014-05-23-
dc.date.available2014-05-23-
dc.date.issued2013-
dc.identifier.issn1661-7800-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/10087-
dc.description.abstractBACKGROUND: Earlier and more accurate identification of a high-risk group of preterm infants that are likely to develop a hemodynamically significant patent ductus arteriosus (hsPDA) would allow specific targeting of early treatment and thus possibly minimize the morbidity and mortality associated with a PDA in extremely low birth weight (ELBW) infants.



OBJECTIVE: To investigate the predictability of B-type natriuretic peptide (BNP) for early targeted treatment of hsPDA in ELBW infants.



METHODS: 73 ELBW infants that underwent echocardiographic evaluation and plasma BNP measurement after birth were enrolled. 31 infants developed hsPDA (HsPDA group) and 42 infants did not develop hsPDA (nPDA group).



RESULTS: BNP levels of the HsPDA group were significantly higher than those of the nPDA group at 24 h of age (921 [318-2,133] vs. 152 [91-450] pg/ml) but not different at 12 h of age. BNP levels at 24 h of age were significantly correlated with the magnitudes of the ductal shunt but not at 12 h of age. The area under the receiver operator characteristic curve of BNP levels for prediction of hsPDA at 24 h of age was 0.830. At the cutoff BNP levels of 200 and 900 pg/ml at 24 h of age, sensitivity was 83.9 and 54.8% and specificity was 61.9 and 95.2%, respectively.



CONCLUSIONS: BNP levels at 24 h of age can be used as a guide for early targeted treatment of hsPDA and avoid the unnecessary use of cyclooxygenase inhibitors in ELBW infants.
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dc.language.isoen-
dc.subject.MESHDuctus Arteriosus, Patent/*diagnosis/ultrasonography-
dc.subject.MESHFemale-
dc.subject.MESHGestational Age-
dc.subject.MESHHumans-
dc.subject.MESHInfant, Extremely Low Birth Weight/*blood-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHInfant, Premature/*blood-
dc.subject.MESHInfant, Premature, Diseases/*blood/ultrasonography-
dc.subject.MESHMale-
dc.subject.MESHNatriuretic Peptide, Brain/*blood-
dc.subject.MESHROC Curve-
dc.subject.MESHRetrospective Studies-
dc.titleCan early B-type natriuretic peptide assays predict symptomatic patent ductus arteriosus in extremely low birth weight infants?-
dc.typeArticle-
dc.identifier.pmid23182972-
dc.identifier.urlhttp://www.karger.com/?DOI=10.1159/000343034-
dc.contributor.affiliatedAuthor이, 장훈-
dc.contributor.affiliatedAuthor박, 문성-
dc.type.localJournal Papers-
dc.identifier.doi10.1159/000343034-
dc.citation.titleNeonatology-
dc.citation.volume103-
dc.citation.number2-
dc.citation.date2013-
dc.citation.startPage118-
dc.citation.endPage122-
dc.identifier.bibliographicCitationNeonatology, 103(2):118-122, 2013-
dc.identifier.eissn1661-7819-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
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