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Cited 18 times in

Survival of Alzheimer's disease patients in Korea.

DC Field Value Language
dc.contributor.authorGo, SM-
dc.contributor.authorLee, KS-
dc.contributor.authorSeo, SW-
dc.contributor.authorChin, J-
dc.contributor.authorKang, SJ-
dc.contributor.authorMoon, SY-
dc.contributor.authorNa, DL-
dc.contributor.authorCheong, HK-
dc.date.accessioned2014-05-26T01:40:39Z-
dc.date.available2014-05-26T01:40:39Z-
dc.date.issued2013-
dc.identifier.issn1420-8008-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/10129-
dc.description.abstractBACKGROUND/AIMS: The natural history of Alzheimer's disease (AD) has rarely been studied in the Korean population. Our study on survival analyses in Korean AD patients potentially provides a basis for cross-cultural comparisons.



METHODS: We studied 724 consecutive patients from a memory disorder clinic in a tertiary hospital in Seoul, who were diagnosed as having AD between April 1995 and December 2005. Deaths were identified by the Statistics Korea database. The Kaplan-Meier method was used for survival analysis, and a Cox proportional hazard model was used to assess factors related to patient survival.



RESULTS: The overall median survival from the onset of first symptoms and from the time of diagnosis was 12.6 years (95% confidence interval 11.7-13.4) and 9.3 years (95% confidence interval 8.7-9.9), respectively. The age of onset, male gender, history of diabetes mellitus, lower Mini-Mental State Examination score, and higher Clinical Dementia Rating score were negatively associated with survival. There was a reversal of risk of AD between early-onset and later-onset AD, 9.1 years after onset.



CONCLUSIONS: The results of our study show a different pattern of survival compared to those studies carried out with western AD populations. Mortality risk of early-onset AD varied depending on the duration of follow-up.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAge of Onset-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAlzheimer Disease/ethnology/*mortality-
dc.subject.MESHCross-Cultural Comparison-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHVital Statistics-
dc.titleSurvival of Alzheimer's disease patients in Korea.-
dc.typeArticle-
dc.identifier.pmid23467314-
dc.identifier.urlhttp://www.karger.com/?DOI=10.1159/000347133-
dc.contributor.affiliatedAuthor문, 소영-
dc.type.localJournal Papers-
dc.identifier.doi10.1159/000347133-
dc.citation.titleDementia and geriatric cognitive disorders-
dc.citation.volume35-
dc.citation.number3-4-
dc.citation.date2013-
dc.citation.startPage219-
dc.citation.endPage228-
dc.identifier.bibliographicCitationDementia and geriatric cognitive disorders, 35(3-4):219-228, 2013-
dc.identifier.eissn1421-9824-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
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