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Correlation between instrumental activities of daily living and white matter hyperintensities in amnestic mild cognitive impairment: results of a cross-sectional study.

Authors
Yoon, B; Shim, YS; Kim, YD; Lee, KO; Na, SJ; Hong, YJ; Oh, YS; Na, DL; Seo, SW; Park, KW; Moon, SY; Kim, SY; Lee, JH; Choi, SH; Yang, DW
Citation
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 34(5):715-721, 2013
Journal Title
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN
1590-18741590-3478
Abstract
Although some studies have supported the association between white matter hyperintensities (WMH) and cognitive impairment, whether WMH are associated with the impairments in instrumental activities of daily living (IADLs) remains unknown. This cross-sectional study investigated differences in basic ADLs and IADLs among different severity of WMH in a large, well-defined registry of patients with amnestic mild cognitive impairment (aMCI). 1,514 patients with aMCI were divided into three groups according to the degree of WMH (1,026 mild, 393 moderate, and 95 severe). We compared the total IADL scores and analyzed the prevalence of the impairment for each IADL item for each group. The severity of WMH was associated with the impairments in IADLs. Among 15 Seoul IADL items, "using public transportation", "going out (short distance)", "grooming" and "participating in leisure activities/hobbies" showed greater positive association with the severity of WMH. WMH in patients with aMCI were associated with the impairments in IADLs but not in basic ADLs. These findings are likely to be more obvious with respect to using public transportation, going out (short distances), shopping, grooming and participating in leisure activities/hobbies.
MeSH terms
*Activities of Daily LivingAgedAged, 80 and over*Amnesia/complications/pathology/psychologyBrain/*pathologyCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle Aged*Mild Cognitive Impairment/complications/pathology/psychologyNerve Fibers, Myelinated/*pathologyNeuropsychological TestsOdds RatioRepublic of KoreaRetrospective Studies
DOI
10.1007/s10072-012-1120-z
PMID
22639097
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
문, 소영
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