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Morbidity of solid cancer in Behςet's disease: analysis of 11 cases in a series of 506 patients.

Authors
Na, SY; Shin, J; Lee, ES
Citation
Yonsei medical journal, 54(4):895-901, 2013
Journal Title
Yonsei medical journal
ISSN
0513-57961976-2437
Abstract
PURPOSE: Behςet's disease (BD) is rarely reported to be associated with malignancies in the literature. However, the frequency of cancer in BD patients remains unknown. This study evaluated cancer morbidity in BD patients compared with that in the general population of Korea.



MATERIALS AND METHODS: A retrospective chart review was performed on 506 patients visiting our hospital from 1994 to 2011 for BD. We analyzed the standardized morbidity rate (SMR), which is the ratio of observed to expected malignancies. Furthermore, we reviewed cases of solid cancer in BD patients in the literature.



RESULTS: Of the 506 patients with BD, 11 (2.17%) developed cancer. We found a variety of solid cancers without predominance and no hematologic malignancies. The total number of cancers observed was less than expected, which was determined from the statistical data of the National Cancer Information Center of Korea, with an SMR of 0.023 (95% confidence interval, 0.012-0.039).



CONCLUSION: BD may be associated with a lower cancer-related morbidity compared with the general population of Korea.
MeSH terms
AdultBehcet Syndrome/*complications/drug therapy/epidemiologyFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasms/*epidemiology/etiology/surgeryRepublic of Korea/epidemiologyRetrospective Studies
DOI
10.3349/ymj.2013.54.4.895
PMID
23709423
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
이, 은소
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