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Surgical outcomes of hepatocellular carcinoma with bile duct tumor thrombus: a Korean multicenter study.

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dc.contributor.authorMoon, DB-
dc.contributor.authorHwang, S-
dc.contributor.authorWang, HJ-
dc.contributor.authorYun, SS-
dc.contributor.authorKim, KS-
dc.contributor.authorLee, YJ-
dc.contributor.authorKim, KH-
dc.contributor.authorPark, YK-
dc.contributor.authorXu, W-
dc.contributor.authorKim, BW-
dc.contributor.authorLee, DS-
dc.contributor.authorLee, DH-
dc.contributor.authorKim, HJ-
dc.contributor.authorLim, JH-
dc.contributor.authorChoi, JS-
dc.contributor.authorPark, YH-
dc.contributor.authorLee, SG-
dc.date.accessioned2014-05-27T01:09:28Z-
dc.date.available2014-05-27T01:09:28Z-
dc.date.issued2013-
dc.identifier.issn0364-2313-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/10171-
dc.description.abstractBACKGROUND: The long-term outcomes after resection for hepatocellular carcinoma (HCC) with macroscopic bile duct tumor thrombus (BDTT) are unclear. This multicenter study was conducted to determine the prognosis of HCC patients with macroscopic BDTT who underwent resection with curative intent.



METHODS: Of 4,308 patients with HCC from four Korean institutions, this single-arm retrospective study included 73 patients (1.7 %) who underwent resection for HCC with BDTT.



RESULTS: Jaundice was also present in 34 patients (46.6 %). According to Ueda classification, BDTT was type 2 in 34 cases (46.6 %) and type 3 in 39 cases (53.4 %). Biliary decompression was performed in 33 patients (45.2 %), decreasing the median lowest bilirubin level to 1.4 mg/dL before surgery. Systematic hepatectomy was performed in 69 patients (94.5 %), and concurrent bile duct resection was performed in 31 patients (42.5 %). Surgical curability types were R0 (n = 57; 78.1 %), R1 (n = 11; 15.1 %), and R2 (n = 5; 6.8 %). Patient survival rates were 76.5 % at 1 year, 41.4 % at 3 years, 32.0 % at 5 years, and 17.0 % at 10 years. Recurrence rates were 42.9 % at 1 year, 70.6 % at 3 years, 77.3 % at 5 years, and 81.1 % at 10 years. Results of univariate survival analysis showed that maximal tumor size, bile duct resection, and surgical curability were significant risk factors for survival, and surgical curability was a significant risk factor for recurrence. Multivariate analysis did not reveal any independent risk factors.



CONCLUSIONS: Hepatocellular carcinoma patients with BDTT achieved relatively favorable long-term results after resection; therefore extensive surgery should be recommended when complete resection is anticipated.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Hepatocellular-
dc.subject.MESHCholestasis-
dc.subject.MESHFemale-
dc.subject.MESHHepatectomy-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms-
dc.subject.MESHLiver Transplantation-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTreatment Outcome-
dc.titleSurgical outcomes of hepatocellular carcinoma with bile duct tumor thrombus: a Korean multicenter study.-
dc.typeArticle-
dc.identifier.pmid23188531-
dc.contributor.affiliatedAuthor왕, 희정-
dc.contributor.affiliatedAuthor박, 용근-
dc.contributor.affiliatedAuthor김, 봉완-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00268-012-1845-0-
dc.citation.titleWorld journal of surgery-
dc.citation.volume37-
dc.citation.number2-
dc.citation.date2013-
dc.citation.startPage443-
dc.citation.endPage451-
dc.identifier.bibliographicCitationWorld journal of surgery, 37(2). : 443-451, 2013-
dc.identifier.eissn1432-2323-
dc.relation.journalidJ003642313-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
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