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Comparison of oncological outcomes between neoadjuvant and adjuvant chemotherapy combined with surgery for resectable synchronous colorectal liver metastases.

Authors
Oh, SY; Kim, do Y; Kim, YB; Suh, KW
Citation
The Journal of surgical research, 182(2):257-263, 2013
Journal Title
The Journal of surgical research
ISSN
0022-48041095-8673
Abstract
BACKGROUND: The role of neoadjuvant chemotherapy for resectable colorectal liver metastases is a subject of debate. We compared the oncologic outcomes between neoadjuvant chemotherapy and adjuvant chemotherapy combined with surgery for resectable synchronous colorectal liver metastases.



METHODS: We analyzed 30 patients who underwent liver resection for resectable colorectal liver metastases combined with oxaliplatin-based neoadjuvant or adjuvant chemotherapy between May 2003 and August 2010. We assessed recurrence-free and overall survival in patients treated using neoadjuvant chemotherapy compared with those who received adjuvant chemotherapy.



RESULTS: Of the 30 patients with colorectal liver metastases, 15 underwent neoadjuvant chemotherapy and 15 underwent adjuvant chemotherapy. Nine (60%) patients in the adjuvant group relapsed and nine (60%) patients in the neoadjuvant group relapsed. The neoadjuvant chemotherapy group had no significant difference in recurrence-free and overall 3-y survival (37.5% versus 45.0%, P = 0.938; 44.0% versus 66.7 %, P = 0.466) compared with the adjuvant chemotherapy group.



CONCLUSION: Our results indicate that neoadjuvant chemotherapy is not inferior to adjuvant chemotherapy for resectable colorectal liver metastases, although the study was not randomized and included a limited number of patients.
MeSH terms
AdultAgedChemotherapy, AdjuvantColorectal Neoplasms/*pathologyCombined Modality TherapyFemaleHumansLiver Neoplasms/mortality/*secondary/*therapyMaleMiddle AgedNeoadjuvant TherapyNeoplasms, Multiple Primary/*therapyTreatment Outcome
DOI
10.1016/j.jss.2012.10.927
PMID
23253254
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
AJOU Authors
오, 승엽김, 도윤김, 영배서, 광욱
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