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Increased expression of Toll-like receptor 5 during progression of cervical neoplasia.

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dc.contributor.authorKim, WY-
dc.contributor.authorLee, JW-
dc.contributor.authorChoi, JJ-
dc.contributor.authorChoi, CH-
dc.contributor.authorKim, TJ-
dc.contributor.authorKim, BG-
dc.contributor.authorSong, SY-
dc.contributor.authorBae, DS-
dc.date.accessioned2011-01-06T05:21:29Z-
dc.date.available2011-01-06T05:21:29Z-
dc.date.issued2008-
dc.identifier.issn1048-891X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1018-
dc.description.abstractThe purpose of this study was to determine whether Toll-like receptor 5 (TLR5) expression was associated with disease progression in cervical neoplasia. TLR5 expression was evaluated by immunohistochemistry (IHC) in 55 formalin-fixed paraffin-embedded cervical tissues; 10 normal cervical specimens, 9 low-grade cervical intraepithelial neoplasias (CINs), 12 high-grade CINs, and 24 invasive squamous cell carcinomas (ISCCs). TLR5 expression was also evaluated at the RNA level, in fresh, frozen cervical carcinoma tissues by real-time quantitative RT-PCR. TLR5 expression, which was mainly observed as cytoplasmic staining, gradually increased in accordance with the histopathologic grade in the following order: low-grade CIN less than high-grade CIN less than ISCC (P < 0.001). Immunohistochemical staining showed that TLR5 expression was undetectable (80%) or weak (20%) in normal cervical squamous epithelial tissues. However, moderate expression was detected in 33.3% of low-grade CIN (3/9), 41.7% of high-grade CIN (5/12), and 45.8% of ISCC (11/24). Strong expression was detected in as much as 33.3% of high-grade CIN (4/12) and 50% of ISCC (12/24). Contrary to IHC results, real-time quantitative RT-PCR revealed that TLR5 expression in tumors was not statistically different compared to normal cervical tissues (P = 0.1452). The IHC result suggests that TLR5 may play a significant role in tumor progression of cervical neoplasia and may represent a useful marker for malignant transformation of cervical squamous cells.-
dc.language.isoen-
dc.subject.MESHCarcinoma, Squamous Cell-
dc.subject.MESHCervical Intraepithelial Neoplasia-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHToll-Like Receptor 5-
dc.subject.MESHTumor Markers, Biological-
dc.subject.MESHUterine Cervical Neoplasms-
dc.titleIncreased expression of Toll-like receptor 5 during progression of cervical neoplasia.-
dc.typeArticle-
dc.identifier.pmid17587322-
dc.contributor.affiliatedAuthor김, 우영-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/j.1525-1438.2007.01008.x-
dc.citation.titleInternational journal of gynecological cancer-
dc.citation.volume18-
dc.citation.number2-
dc.citation.date2008-
dc.citation.startPage300-
dc.citation.endPage305-
dc.identifier.bibliographicCitationInternational journal of gynecological cancer, 18(2). : 300-305, 2008-
dc.identifier.eissn1525-1438-
dc.relation.journalidJ01048891X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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