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Safety and immunogenicity of a vaccine targeting human papillomavirus types 6, 11, 16 and 18: a randomized, placebo-controlled trial in 176 Korean subjects.

Authors
Kang, S; Kim, KH; Kim, YT; Kim, JH; Song, YS; Shin, SH; Ryu, HS; Han, JW; Kang, JH; Park, SY
Citation
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 18(5):1013-1019, 2008
Journal Title
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
ISSN
1048-891X1525-1438
Abstract
Human papillomavirus (HPV) is a major causative agent of anogenital warts and a necessary cause of cervical cancer. This report will serve to assess the safety and immunogenicity of quadrivalent (types 6, 11, 16, and 18) HPV L1 virus-like particle (VLP) vaccine in the Korean population. We performed a randomized, double-blind, placebo-controlled study in 176 volunteers aged 9-23 years. Using a 2:1 ratio for randomization, 117 women were assigned to quadrivalent HPV (20 mug type 6, 40 mug type 11, 40 mug type 16, and 20 mug type 18) vaccine and 59 women to placebo. Individuals received vaccine at day 1, month 2, and month 6 and provided blood samples for analysis at enrollment at month 7. Analyses were done as specified in the study protocol. Quadrivalent HPV vaccine was generally well tolerated, with no vaccine-related serious adverse experiences. Quadrivalent HPV vaccine induced seroconversion for each vaccine-related HPV type. At month 7, vaccine-induced type-specific antibody titer was high. In conclusion, administration of quadrivalent HPV VLP vaccine to Korean women aged 9-23 years was generally well tolerated and highly immunogenic.
MeSH terms
AdolescentAlphapapillomavirus/immunology*Antibodies, Viral/bloodAntibodies, Viral/immunologyChildFemaleHumansKoreaPapillomavirus Vaccines/adverse effects*Papillomavirus Vaccines/immunology*Young Adult
DOI
10.1111/j.1525-1438.2007.01123.x
PMID
17986242
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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