Cited 0 times in Scipus Cited Count

Outcome and reproductive function after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for patients with ovarian endodermal sinus tumor.

DC Field Value Language
dc.contributor.authorKang, H-
dc.contributor.authorKim, TJ-
dc.contributor.authorKim, WY-
dc.contributor.authorChoi, CH-
dc.contributor.authorLee, JW-
dc.contributor.authorKim, BG-
dc.contributor.authorBae, DS-
dc.date.accessioned2011-01-06T05:31:57Z-
dc.date.available2011-01-06T05:31:57Z-
dc.date.issued2008-
dc.identifier.issn0090-8258-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1023-
dc.description.abstractOBJECTIVE: The aim of this study was to investigate the outcome and reproductive function of patients with ovarian endodermal sinus tumor (EST) after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP).



METHODS: Between 1995 and 2006, 1034 patients with the diagnosis of ovarian cancer were treated at a single institution. Among these patients, 51 had a confirmed diagnosis of malignant ovarian germ cell tumor (MOGCT) including 20 cases of EST. We retrospectively reviewed those patients with EST, who received BEP as adjuvant chemotherapy. The doses were 15 mg/day of bleomycin on days 1 to 3, 100 mg/m(2)/day IV of etoposide on days 1 to 3 and 20 mg/m(2)/day of cisplatin on days 1 to 5. The median number of total cycles was six (range between three and nine).



RESULTS: The median age of the patients with EST was 18 years (range 5 to 36). All except two were nulliparous. The overall survival rate was 90% at a median follow-up of 70 months. Two patients (10%) had disease recurrence in the pelvis. Of the 15 patients who were treated with fertility-sparing surgery, all had regular menstruation following the completion of adjuvant chemotherapy, and two of these patients had pregnancies with live birth deliveries and no complications.



CONCLUSION: In patients with EST, the cumulative high-dose BEP regimen resulted in excellent overall survival and did not seem to impair ovarian function.
-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols-
dc.subject.MESHBleomycin-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCisplatin-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHEndodermal Sinus Tumor-
dc.subject.MESHEtoposide-
dc.subject.MESHFemale-
dc.subject.MESHFertility-
dc.subject.MESHGynecologic Surgical Procedures-
dc.subject.MESHHumans-
dc.subject.MESHOvarian Neoplasms-
dc.subject.MESHOvary-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titleOutcome and reproductive function after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for patients with ovarian endodermal sinus tumor.-
dc.typeArticle-
dc.identifier.pmid18656249-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0090-8258(08)00428-9-
dc.contributor.affiliatedAuthor김, 우영-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.ygyno.2008.05.033-
dc.citation.titleGynecologic oncology-
dc.citation.volume111-
dc.citation.number1-
dc.citation.date2008-
dc.citation.startPage106-
dc.citation.endPage110-
dc.identifier.bibliographicCitationGynecologic oncology, 111(1). : 106-110, 2008-
dc.identifier.eissn1095-6859-
dc.relation.journalidJ000908258-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse