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The effects of a 1.8 GHz continuous electromagnetic fields on mucociliary transport of human nasal mucosa.

Authors
In, SM | Kim, HJ  | Park, RW  | Kim, W | Gimm, YM | Park, I | Hong, S | Hong, JJ  | Oh, JH | Kahng, H | Park, EY
Citation
The Laryngoscope, 123(2). : 315-320, 2013
Journal Title
The Laryngoscope
ISSN
0023-852X1531-4995
Abstract
OBJECTIVES/HYPOTHESIS: The aim of this study was to investigate the effects of a 1.8 GHz continuous electromagnetic fields (EMF) on human nasal mucociliary transport, and to determine the pathophysiology of ciliary beat frequency (CBF) during an EMF-induced change.



METHODS: Human nasal mucosa cells were exposed to a 1.8 GHz EMF (SAR=1.0 W/kg), and CBF was analyzed using an optical flow technique with the peak detection method.



RESULTS: The 1.8 GHz-exposed group showed a decreased CBF when compared to the control group. In the cytotoxicity assay, difference in survival rates was not found between the two groups. In the EMF-exposed group, protein kinase C (PKC) activity was increased during a PKC activity assay. The broad PKC inhibitor, Calphostin C abolished the EMF-induced decrease of CBF. The EMF-induced decrease of CBF was abolished by GF 109203X, a novel PKC (nPKC) isoform inhibitor, whereas the decrease was not attenuated by Gö-6976, a specific inhibitor of conventional PKC (cPKC) isoform.



CONCLUSIONS: EMF may inhibit CBF via an nPKC-dependent mechanism. Therefore, we have confirmed that EMF could decrease CBF by increasing PKC activity.
MeSH

DOI
10.1002/lary.23620
PMID
23060235
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
Journal Papers > School of Medicine / Graduate School of Medicine > Biomedical Informatics
Ajou Authors
김, 현준  |  박, 래웅  |  홍, 정주
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