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Intubation time required for tracheal intubation with low-dose rocuronium in children with and without atropine.

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dc.contributor.authorKwak, HJ-
dc.contributor.authorMin, SK-
dc.contributor.authorMoon, BK-
dc.contributor.authorLee, KC-
dc.contributor.authorKim, YB-
dc.contributor.authorKim, JY-
dc.date.accessioned2014-05-30T05:15:32Z-
dc.date.available2014-05-30T05:15:32Z-
dc.date.issued2013-
dc.identifier.issn0913-8668-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/10282-
dc.description.abstractPURPOSE: The purpose of this study was to determine the intubation time needed to facilitate tracheal intubation (Time(EI)) with a low dose of rocuronium (0.3 mg/kg) during propofol induction, and to determine whether this time was reduced by the administration of atropine.



METHODS: Forty-six children, aged 3-10 years, were randomly assigned to receive either saline (control group) or atropine 10 μg/kg (atropine group). Anesthesia was induced with alfentanil 10 μg/kg, propofol 2.5 mg/kg, and rocuronium 0.3 mg/kg. Each Time(EI) at which tracheal intubation was attempted was predetermined according to the up-and-down method. The values of Time(EI) that provided excellent intubation conditions in 50 and 95 % of patients were defined as Time(EI)50 and Time(EI)95, respectively.



RESULTS: Time(EI)50 ± SD was 160 ± 26.2 and 150 ± 13.7 s in the control and atropine groups, respectively. Using isotonic regression, Time(EI)95 in the control and atropine groups was 199 s (95 % CI 198.8-200.7 s) and 171 s (95 % CI 171.3-172.1 s), respectively. Time(EI)95 was significantly higher in the control group than in the atropine group (P < 0.001). HR was significantly higher in the atropine group than in the control group during the study period.



CONCLUSIONS: This study demonstrated that the Time(EI)95 of a low dose of rocuronium (0.3 mg/kg) required for excellent tracheal intubation was 199 s during i.v. anesthesia induction using propofol and alfentanil in children. Also, i.v. atropine (10 μg/kg) before anesthesia induction was able to reduce Time(EI)95 by 28 s.
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dc.language.isoen-
dc.subject.MESHAndrostanols-
dc.subject.MESHAnesthesia-
dc.subject.MESHArterial Pressure-
dc.subject.MESHAtropine-
dc.subject.MESHCardiac Output-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCough-
dc.subject.MESHFemale-
dc.subject.MESHHeart Rate-
dc.subject.MESHHumans-
dc.subject.MESHIntubation, Intratracheal-
dc.subject.MESHMale-
dc.subject.MESHMuscarinic Antagonists-
dc.subject.MESHNeuromuscular Nondepolarizing Agents-
dc.subject.MESHTime Factors-
dc.subject.MESHTonsillectomy-
dc.titleIntubation time required for tracheal intubation with low-dose rocuronium in children with and without atropine.-
dc.typeArticle-
dc.identifier.pmid22983593-
dc.contributor.affiliatedAuthor민, 상기-
dc.contributor.affiliatedAuthor문, 봉기-
dc.contributor.affiliatedAuthor김, 종엽-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00540-012-1489-0-
dc.citation.titleJournal of anesthesia-
dc.citation.volume27-
dc.citation.number2-
dc.citation.date2013-
dc.citation.startPage199-
dc.citation.endPage204-
dc.identifier.bibliographicCitationJournal of anesthesia, 27(2). : 199-204, 2013-
dc.identifier.eissn1438-8359-
dc.relation.journalidJ009138668-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
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