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Magnetic resonance imaging enhancement features before and after neoadjuvant chemotherapy in patients with breast cancer: a predictive value for responders.

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dc.contributor.authorKang, DK-
dc.contributor.authorKim, TH-
dc.contributor.authorHan, TS-
dc.contributor.authorKim, KS-
dc.contributor.authorYim, H-
dc.date.accessioned2014-05-30T05:52:59Z-
dc.date.available2014-05-30T05:52:59Z-
dc.date.issued2013-
dc.identifier.issn0363-8715-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/10293-
dc.description.abstractPURPOSE: This study examined the ability of magnetic resonance imaging (MRI) enhancement features to predict the response to neoadjuvant chemotherapy (NAC) in patients with breast cancer.



METHODS: This retrospective study included 107 patients with breast cancer. All patients underwent a baseline breast MRI before NAC and follow-up MRI a mean of 3.7 months later. Breast MRI scans were evaluated using the Breast Imaging Reporting and Data System MRI lexicon. In addition, whole-breast vascularity (WBV) in the cancer-bearing breast was graded according to increased vessel number in comparison with the contralateral breast. Histopathologic tumor regression was graded semiquantitatively based on the Miller-Payne grading system. The ability of each MRI feature to predict the response was evaluated using a logistic regression analysis. Correlations between changes in MRI features and response were also evaluated using the Spearman rank correlation test.



RESULTS: There were 73 responders (68%), including 59 partial and 14 complete responders. No significant difference in baseline MRI features was found between the responders and nonresponders, except for tumor size (P = 0.044). No dynamic enhancement feature on baseline MRI was useful for the early prediction of a response. In addition, an increased WBV did not predict a response, and the WBV change on the follow-up MRI was not correlated with the response. However, the change in the initial enhancement pattern (P = 0.007) and kinetic curve type (P = 0.003) were significantly correlated with response.



CONCLUSIONS: No baseline MRI feature described using the Breast Imaging Reporting and Data System MRI lexicon was useful for early prediction of the response to NAC.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols-
dc.subject.MESHBreast Neoplasms-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHContrast Media-
dc.subject.MESHFemale-
dc.subject.MESHGadolinium DTPA-
dc.subject.MESHHumans-
dc.subject.MESHImage Enhancement-
dc.subject.MESHLogistic Models-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoadjuvant Therapy-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStatistics, Nonparametric-
dc.subject.MESHTreatment Outcome-
dc.titleMagnetic resonance imaging enhancement features before and after neoadjuvant chemotherapy in patients with breast cancer: a predictive value for responders.-
dc.typeArticle-
dc.identifier.pmid23674017-
dc.identifier.urlhttp://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0363-8715&volume=37&issue=3&spage=432-
dc.contributor.affiliatedAuthor강, 두경-
dc.contributor.affiliatedAuthor김, 태희-
dc.contributor.affiliatedAuthor김, 구상-
dc.contributor.affiliatedAuthor임, 현이-
dc.type.localJournal Papers-
dc.identifier.doi10.1097/RCT.0b013e31828386ae-
dc.citation.titleJournal of computer assisted tomography-
dc.citation.volume37-
dc.citation.number3-
dc.citation.date2013-
dc.citation.startPage432-
dc.citation.endPage439-
dc.identifier.bibliographicCitationJournal of computer assisted tomography, 37(3). : 432-439, 2013-
dc.identifier.eissn1532-3145-
dc.relation.journalidJ003638715-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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