84 269

Cited 7 times in

Genome-wide association study of serum albumin:globulin ratio in Korean populations.

Authors
Hong, KW; Jin, HS; Song, D; Kwak, HK; Kim, SS; Kim, Y
Citation
Journal of human genetics, 58(3):174-177, 2013
Journal Title
Journal of human genetics
ISSN
1434-51611435-232X
Abstract
Low albumin:globulin (A/G) ratios are associated with vascular adverse events, nephrotic syndrome and autoimmune disease. Genome-wide association studies (GWASs) have been identifying genetic variants associated with total serum protein, serum albumin and globulins, but A/G ratio has never been considered the target phenotype. To identify the genetic basis of the A/G ratio, we performed a GWAS on A/G ratio in 4205 individuals from the Ansan cohort and confirmed the results in 4637 subjects from the Ansung cohort. The single-nucleotide polymorphism (SNP) genotypes of Affymetrix SNP array 5.0 were obtained from the Korean Association Resource Consortium, and we selected 290 659 common SNPs with a minor allele frequency >0.05. Genetic factors for A/G ratio were analyzed by linear regression analysis, controlling for age, sex, body mass index, smoking status and alcohol drinking status as covariates. From the GWAS of the Ansan cohort, we identified two significant genome-wide signals (P-values<5 × 10(-8)) and 36 moderate signals (P-value<1.0 × 10(-4)). These 38 signals were tested in the Ansung population. Eleven SNPs from six loci (GALNT2, IRF4, HLA-DBP1, SLC31A1, FADS1 and TNFRSF13B) were replicated, with P-values<0.05. The most compelling association was observed in the TNFRSF13B locus on chromosome 17p11.2 (SNP: rs4561508), with an overall combined P-value=7.80 × 10(-24). The other significant signal was observed on chromosome 11q12.2-the FADS1 locus (SNP: rs174548)-with an overall combined P-value=3.54 × 10(-8).
MeSH terms
AdultAgedAsian Continental Ancestry Group/geneticsChromosomes, Human, Pair 11/geneticsChromosomes, Human, Pair 17/geneticsCohort StudiesFatty Acid Desaturases/geneticsFemaleGene FrequencyGenetic LociGenetic Predisposition to Disease*Genome-Wide Association StudyHumansLinear ModelsLinkage DisequilibriumMaleMiddle Aged*Polymorphism, Single NucleotideRepublic of KoreaSerum Albumin/*analysis/geneticsSerum Globulins/*analysis/geneticsTransmembrane Activator and CAML Interactor Protein/genetics
DOI
10.1038/jhg.2012.130
PMID
23303382
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Genetics
AJOU Authors
진, 현석
Files in This Item:
fulltext not available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse