Cited 0 times in Scipus Cited Count

The role of peroxiredoxin III in the ototoxic drug-induced mitochondrial apoptosis of cochlear hair cells.

DC Field Value Language
dc.contributor.authorChoi, HS-
dc.contributor.authorPark, KJ-
dc.contributor.authorHwang, SC-
dc.contributor.authorPark, HY-
dc.contributor.authorKim, YS-
dc.contributor.authorPark, K-
dc.date.accessioned2011-01-06T05:45:40Z-
dc.date.available2011-01-06T05:45:40Z-
dc.date.issued2008-
dc.identifier.issn0001-6489-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1034-
dc.description.abstractCONCLUSION: Peroxiredoxin (Prx) III plays a protective role in cisplatin- and gentamicin-induced apoptosis via a mitochondria-dependent pathway in cochlear hair cells.



OBJECTIVES: The aim of the present study was to investigate the effects of the depletion of endogenous Prx III on oxidative damage to mitochondrial components and on apoptotic events with the use of RNA interference.



MATERIALS AND METHOD: . Depletion of Prx III was done by RNA interference in cochlear hair cells (UB/OC-1), and cells were exposed to ototoxic drugs (cisplatin or gentamicin). We then compared the apoptotic signaling between Prx III-depleted and control cells.



RESULTS: The depletion of Prx III resulted in increased intracellular ROS levels accompanied by enhanced apoptosis by ototoxic drugs. The Prx III-depleted cells showed mitochondrial membrane potential collapse, cytochrome c release, and caspase activation.
-
dc.language.isoen-
dc.subject.MESHAnti-Bacterial Agents-
dc.subject.MESHAntineoplastic Agents-
dc.subject.MESHApoptosis-
dc.subject.MESHCell Culture Techniques-
dc.subject.MESHCisplatin-
dc.subject.MESHCochlea-
dc.subject.MESHGentamicins-
dc.subject.MESHHair Cells, Auditory-
dc.subject.MESHHumans-
dc.subject.MESHIn Situ Nick-End Labeling-
dc.subject.MESHMitochondria-
dc.subject.MESHOxidative Stress-
dc.subject.MESHPeroxiredoxins-
dc.subject.MESHRNA Interference-
dc.subject.MESHReactive Oxygen Species-
dc.titleThe role of peroxiredoxin III in the ototoxic drug-induced mitochondrial apoptosis of cochlear hair cells.-
dc.typeArticle-
dc.identifier.pmid19086304-
dc.contributor.affiliatedAuthor박, 광주-
dc.contributor.affiliatedAuthor황, 성철-
dc.contributor.affiliatedAuthor박, 헌이-
dc.contributor.affiliatedAuthor박, 기현-
dc.type.localJournal Papers-
dc.identifier.doi10.1080/00016480701805463-
dc.citation.titleActa oto-laryngologica-
dc.citation.volume128-
dc.citation.number9-
dc.citation.date2008-
dc.citation.startPage944-
dc.citation.endPage951-
dc.identifier.bibliographicCitationActa oto-laryngologica, 128(9). : 944-951, 2008-
dc.identifier.eissn1651-2251-
dc.relation.journalidJ000016489-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse