Cited 0 times in
Epicatechin protects auditory cells against cisplatin-induced death.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, CH | - |
dc.contributor.author | Kang, SU | - |
dc.contributor.author | Pyun, J | - |
dc.contributor.author | Lee, MH | - |
dc.contributor.author | Hwang, HS | - |
dc.contributor.author | Lee, H | - |
dc.date.accessioned | 2011-01-06T05:47:05Z | - |
dc.date.available | 2011-01-06T05:47:05Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1360-8185 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/1035 | - |
dc.description.abstract | Cisplatin, a chemotherapeutic drug that is widely used to treat various cancers, promotes ototoxicity at higher doses. In this study, the effect of epicatechin (EC) on cisplatin-induced hair cell death was investigated in a cochlear organ of Corti-derived cell line, HEI-OC1, and in vivo in zebrafish. Cisplatin promoted apoptosis and altered mitochondrial membrane potential (MMP) in HEI-OC1 cells. EC inhibited cisplatin-induced apoptosis and intracellular reactive oxygen species (ROS) generation. Labeling of zebrafish lateral line hair cells by the fluorescent dye YO-PRO1 was lost upon exposure to cisplatin, and EC protected against this cisplatin-induced loss of labeling in a dose-dependent manner. Scanning and transmission electron micrographs showed that treatment with EC protected against cisplatin-induced loss of kinocilium and stereocilia in zebrafish neuromasts. These results suggest that EC prevents cisplatin-induced ototoxicity by blocking ROS generation and by preventing changes in MMP. | - |
dc.language.iso | en | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Caspase 3 | - |
dc.subject.MESH | Catechin | - |
dc.subject.MESH | Cell Death | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cell Survival | - |
dc.subject.MESH | Cisplatin | - |
dc.subject.MESH | Cytoprotection | - |
dc.subject.MESH | Hair Cells, Auditory | - |
dc.subject.MESH | Membrane Potential, Mitochondrial | - |
dc.subject.MESH | Reactive Oxygen Species | - |
dc.subject.MESH | Zebrafish | - |
dc.title | Epicatechin protects auditory cells against cisplatin-induced death. | - |
dc.type | Article | - |
dc.identifier.pmid | 18670884 | - |
dc.contributor.affiliatedAuthor | 김, 철호 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s10495-008-0242-5 | - |
dc.citation.title | Apoptosis : an international journal on programmed cell death | - |
dc.citation.volume | 13 | - |
dc.citation.number | 9 | - |
dc.citation.date | 2008 | - |
dc.citation.startPage | 1184 | - |
dc.citation.endPage | 1194 | - |
dc.identifier.bibliographicCitation | Apoptosis : an international journal on programmed cell death, 13(9). : 1184-1194, 2008 | - |
dc.identifier.eissn | 1573-675X | - |
dc.relation.journalid | J013608185 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.