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Efficacy and safety of high concentration lidocaine for trigeminal nerve block in patients with trigeminal neuralgia.
|dc.description.abstract||AIMS: Local anaesthetics, which act as neurolytics and Na(+) channel blockers, have been used for disrupting the neural firings in certain neuropathic pain conditions. This study was undertaken to investigate the clinical outcome of trigeminal nerve block with 10% lidocaine in the management of trigeminal neuralgia (TN).|
METHODS: Thirty-five patients with primary TN received trigeminal nerve blocks with 10% lidocaine. Success was defined as complete pain relief or mild pain without medication 1 day after the treatment. We followed the patients up every 2 months assessing for pain recurrence, sensory changes and other complications for a total of 37-45 months (median 43 months).
RESULTS: Twelve of the 35 patients (34.3%) responded favourably to the treatment and were considered as success. Eleven patients experienced complete pain relief and one could tolerate pain without medication 1 day after the blocks, which lasted for 3-172 weeks. Four patients experienced mildly decreased sensation in the region of the face supplied by the nerve 1 day after the blocks; however, all recovered normal skin sensation in 6 months. There was neither allodynia nor other sensory discomfort. The pain intensity and current pain duration before treatment were significantly different between the two groups.
CONCLUSION: Trigeminal nerve block with high concentration lidocaine (10%) is capable of achieving an intermediate period of pain relief, particularly in patients with lower pain intensity and shorter pain duration prior to the procedure.
|dc.subject.MESH||Anesthetics, Local/administration & dosage*||-|
|dc.subject.MESH||Anesthetics, Local/adverse effects||-|
|dc.subject.MESH||Lidocaine/administration & dosage*||-|
|dc.subject.MESH||Nerve Block/adverse effects||-|
|dc.title||Efficacy and safety of high concentration lidocaine for trigeminal nerve block in patients with trigeminal neuralgia.||-|
|dc.citation.title||International journal of clinical practice||-|
|dc.identifier.bibliographicCitation||International journal of clinical practice, 62(2):248-254, 2008||-|
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