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Prevention of rocuronium-induced withdrawal movement in children: a comparison of remifentanil with alfentanil.

DC Field Value Language
dc.contributor.authorKim, JY-
dc.contributor.authorKwak, HJ-
dc.contributor.authorPark, KS-
dc.contributor.authorSong, JS-
dc.date.accessioned2011-01-07T02:14:43Z-
dc.date.available2011-01-07T02:14:43Z-
dc.date.issued2008-
dc.identifier.issn1155-5645-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1043-
dc.description.abstractBACKGROUND: This study was designed to compare the efficacy of remifentanil and alfentanil without the venous occlusion technique in preventing the withdrawal response associated with rocuronium injection in children.



METHODS: One hundred and twenty children aged between 3 and 10 years were randomly allocated into one of four groups to receive either i.v. remifentanil 0.5 microg.kg(-1) (remi 0.5 group), remifentanil 1 microg.kg(-1) (remi 1.0 group), alfentanil 15 microg.kg(-1) (alfentanil group) or saline 5 ml (saline group). Anesthesia was induced with 2.5% thiopental sodium 5 mg.kg(-1) and the test drug was injected over 30 s. One minute later, 1% rocuronium 0.6 mg.kg(-1) was injected over 5 s and the response was recorded. Mean arterial pressure (MAP) and heart rate (HR) were recorded on arrival in the operating room, before and 1 min after tracheal intubation.



RESULTS: The incidence of withdrawal movement in the saline group (93%) was significantly higher than that in the remi 0.5, remi 1.0, and alfentanil groups (53%, 17%, and 20%, respectively) (P < 0.05). The incidence in the remi 1.0 and alfentanil groups was significantly less than that in the remi 0.5 group (P < 0.05). After intubation, MAP and HR were significantly higher in the saline group than that in remi 1.0 and alfentanil groups.



CONCLUSIONS: Both remifentanil 1 microg.kg(-1) and alfentanil 15 microg.kg(-1) can be used to prevent rocuronium-associated withdrawal movement in children because they are equally effective and attenuate the increase in MAP and HR after intubation.
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dc.language.isoen-
dc.subject.MESHAlfentanil-
dc.subject.MESHAnalgesics, Opioid-
dc.subject.MESHAndrostanols-
dc.subject.MESHBlood Pressure-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHHeart Rate-
dc.subject.MESHHumans-
dc.subject.MESHIntubation, Intratracheal-
dc.subject.MESHMale-
dc.subject.MESHMovement-
dc.subject.MESHNeuromuscular Nondepolarizing Agents-
dc.subject.MESHPain-
dc.subject.MESHPiperidines-
dc.subject.MESHProspective Studies-
dc.titlePrevention of rocuronium-induced withdrawal movement in children: a comparison of remifentanil with alfentanil.-
dc.typeArticle-
dc.identifier.pmid18230068-
dc.identifier.urlhttp://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1155-5645&date=2008&volume=18&issue=3&spage=245-
dc.contributor.affiliatedAuthor김, 종엽-
dc.contributor.affiliatedAuthor박, 관식-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/j.1460-9592.2007.02390.x-
dc.citation.titlePaediatric anaesthesia-
dc.citation.volume18-
dc.citation.number3-
dc.citation.date2008-
dc.citation.startPage245-
dc.citation.endPage250-
dc.identifier.bibliographicCitationPaediatric anaesthesia, 18(3). : 245-250, 2008-
dc.identifier.eissn1460-9592-
dc.relation.journalidJ011555645-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
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