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The effect of lidocaine on remifentanil-induced cough.

Authors
Kim, JY; Park, KS; Kim, JS; Park, JY; Kim, JW
Citation
Anaesthesia, 63(5):495-498, 2008
Journal Title
Anaesthesia
ISSN
0003-24091365-2044
Abstract
This study was performed to investigate the incidence of remifentanil-induced cough and evaluate the efficacy of lidocaine on its prevention. Five-hundred patients, aged 18-70 years, were randomly allocated into two groups to receive either lidocaine 0.5 mg x kg(-1) or 0.9% normal saline intravenously 1 min before remifentanil administration at a target effect-site concentration of 4 ng x ml(-1). Any episode of cough was classified as coughing and graded as mild (1-2), moderate (3-4) or severe (5 or more). We found that the overall incidence of cough was significantly higher in the saline group (69 patients; 27.6%) than that in the lidocaine group (38 patients; 15.2%) (p < 0.001). The results of logistic regression indicated that age and smoking were associated with remifentanil-induced cough. This study demonstrated that intravenously administered lidocaine 0.5 mg x kg(-1) effectively suppresses remifentanil-induced cough without possible systemic lidocaine toxicity.
MeSH terms
AdolescentAdultAge FactorsAgedAnalgesics, Opioid/adverse effects*Anesthetics, Local/therapeutic use*Cough/chemically inducedCough/prevention & control*FemaleHumansInfusions, IntravenousLidocaine/therapeutic use*MaleMiddle AgedPiperidines/adverse effects*Severity of Illness IndexSmoking/adverse effects
DOI
10.1111/j.1365-2044.2007.05414.x
PMID
18412647
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
AJOU Authors
김, 종엽박, 관식김, 진수박, 성용
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