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Pneumatosis Intestinalis Developed due to CMV Infection in a Pediatric Severe Aplastic Anemia Patient after Hematopoietic Stem Cell Transplantation

Other Title
동종조혈모세포이식 한 재생불량빈혈 환자의 거대세포바이러스 감염에 의한 장기종
Authors
선, 민규; 정, 현주; 노, 오규; 박, 준은
Citation
Clinical pediatric hematology-oncology, 20(2):112-115, 2013
Journal Title
Clinical pediatric hematology-oncology
ISSN
2233-52502233-4580
Abstract
A 10-year old girl diagnosed as severe aplastic anemia was transplanted with peripheral stem cells from a CMV seropositive full matched unrelated donor. The conditioning regi-men consisted of busulfan, fludarabine, and anti-thymocyte globulin (ATG). At D+114, abdominal pain, fever, and blood-tinged watery diarrhea developed. At D+116, pneuma-tosis intestinalis (PI) was detected on simple abdominal X-ray and computed tomography (CT). Ganciclovir was started intravenously because CMV antigenemia was detected at D+117. Two days later, PI sign disappeared on simple abdominal X-ray, and hema-tochezia began to decrease. CMV antigenemia disappeared 10 days after starting ganciclovir. We describe a 10-year old girl with severe aplastic anemia who developed PI in the presence of CMV infection and gastro-intestinal graft-versus-host-disease (GVHD) after allogeneic stem cell transplantation and was treated successfully with ganciclovir.
Keywords
Pneumatosis intestinalisCMV infectionGraft-versus-host diseaseHematopoietic stem cell transplantation
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
AJOU Authors
정, 현주노, 오규박, 준은
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