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Parotid gland sparing effect by computed tomography-based modified lower field margin in whole brain radiotherapy

Authors
Cho, O | Chun, M  | Park, SH | Oh, YT  | Kim, MH  | Park, HJ  | Nam, SS | Heo, J | Noh, OK
Citation
Radiation oncology journal, 31(1). : 12-17, 2013
Journal Title
Radiation oncology journal
ISSN
2234-19002234-3164
Abstract
Purpose: Parotid gland can be considered as a risk organ in whole brain radiotherapy (WBRT). The purpose of this study is to evaluate the parotid gland sparing effect of computed tomography (CT)-based WBRT compared to 2-dimensional plan with conventional field margin.



Materials and Methods: From January 2008 to April 2011, 53 patients underwent WBRT using CT-based simulation. Bilateral two-field arrangement was used and the prescribed dose was 30 Gy in 10 fractions. We compared the parotid dose between 2 radiotherapy plans using different lower field margins: conventional field to the lower level of the atlas (CF) and modified field fitted to the brain tissue (MF).



Results: Averages of mean parotid dose of the 2 protocols with CF and MF were 17.4 Gy and 8.7 Gy, respectively (p < 0.001). Mean parotid dose of both glands ≥20 Gy were observed in 15 (28.3%) for CF and in 0 (0.0%) for MF. The whole brain percentage volumes receiving >98% of prescribed dose were 99.7% for CF and 99.5% for MF.



Conclusion: Compared to WBRT with CF, CT-based lower field margin modification is a simple and effective technique for sparing the parotid gland, while providing similar dose coverage of the whole brain.
Keywords

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
Ajou Authors
김, 미화  |  노, 오규  |  박, 혜진  |  오, 영택  |  전, 미선
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