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IGF-1 SIGNALING REGULATES SURVIVAL OF GRAFT NEURAL STEM CELLS IN VITRO AND IN VIVO ATTER SPINAL CORD INJURY

Authors
Hwang, Dong Hoon; Shin, Hae Young; Ryu, Buom-Yong; Kim, Byung Gon
Department
Department of Brain Science
Abstract
*Treadmill training represses neuronal stem cell death after transplantation.

*Interaction between treadmill training exercise and transplanted NSCs increased the volume of spared white matter and enhanced tissue sparing and improves locomotor recovery.

*Interaction between treadmill training exercise and transplanted neural stem cells protects spinal cord injury from secondary degeneration

*Increased IGF-1 is necessary for the stimulatory effects of treadmill training on the transplanted NSCs.

*This study indicates that the treadmill training induced expression of IGF-1 and positively influenced the survival of grafted NSCs.
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