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Protective role of High Mobility Group Box 1(HMGB1) – Toll-like receptor 2 axis on ischemic induced oligodendrocyte death

Authors
Choi, Jun Young; Kim, Byung G.
Department
Department of Brain Science
Abstract
TLR2 provides protective role in oligodendrocyte after ischemia/OGD insult.



OL express HMGB1 and released HMGB1 after OGD in vitro.



HMGB1 inhibition or depletion aggravated OGD induced OL death or ET-1 induced ischemic demyelinating lesion.



Recombinant HMGB1 treatment after OGD rescued OGD induced OL death with TLR2 dependent manner.



These date are suggestive of HMGB1-TLR2 have a protective role ischemia induced OL death and white matter degeneration.
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