43 243

Cited 86 times in

Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk.

Authors
Ryu, M; Kim, EH; Chun, M; Kang, S; Shim, B; Yu, YB; Jeong, G; Lee, JS
Citation
Journal of ethnopharmacology, 115(2):184-193, 2008
Journal Title
Journal of ethnopharmacology
ISSN
0378-87411872-7573
Abstract
Although Astragali Radix (Astragalus, AR), the root of Astragalus membranaceus (Fisch) Bunge, is widely used in oriental medicine for tonifying the immune response and improving circulation, the underlying mechanism(s) by which these effects are induced remains unclear. Here, we report that AR displays anti-inflammatory effects in zymosan air-pouch mice by reducing the expression of iNOS, COX-2, IL-6, IL-1beta and TNF-alpha and by decreasing the production of nitric oxide (NO). In a similar manner, AR reduces the expression of IL-6, iNOS, and COX-2 in lipopolysaccharide (LPS)-treated Raw 264.7 cells. We further demonstrate that AR attenuates the activity of p38 and Erk1/2 and stimulates mitogen-activated protein kinase phosphatase-1 (MKP-1) in LPS-treated Raw 264.7 cells. Additionally, AR interferes with the translocation of NFkappaB to the nucleus, subsequently resulting in NFkappaB-dependent transcriptional repression. Taken together, these data reveal that AR has an anti-inflammatory effect that is mediated by the MKP-1-dependent inactivation of p38 and Erk1/2 and inhibition of NFkappaB-mediated transcription. These results imply that the AR herb has a potential anti-inflammatory activity.
MeSH terms
AnimalsAnti-Inflammatory Agents/pharmacology*Astragalus membranaceus/chemistry*Dual Specificity Phosphatase 1/drug effectsDual Specificity Phosphatase 1/metabolismFemaleGene Expression Regulation/drug effectsInflammation/drug therapy*Medicine, East Asian TraditionalMiceMice, Inbred BALB CMitogen-Activated Protein Kinase 1/drug effectsMitogen-Activated Protein Kinase 1/metabolismMitogen-Activated Protein Kinase 3/drug effectsMitogen-Activated Protein Kinase 3/metabolismNF-kappa B/antagonists & inhibitorsPlant Extracts/pharmacology*Plant RootsTranscription, Genetic/drug effectsp38 Mitogen-Activated Protein Kinases/drug effectsp38 Mitogen-Activated Protein Kinases/metabolism
DOI
10.1016/j.jep.2007.09.027
PMID
17996413
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
AJOU Authors
전미선강승희
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse