46 388

Cited 0 times in

A case of chronic myelogenous leukemia with e8a2 fusion transcript.

Authors
Park, IJ; Lim, YA; Lee, WG; Park, JS; Kim, HC; Lee, HJ; Cho, SR
Citation
Cancer genetics and cytogenetics, 185(2):106-108, 2008
Journal Title
Cancer genetics and cytogenetics
ISSN
0165-46081873-4456
Abstract
The Philadelphia chromosome and its corresponding fusion gene, BCR-ABL, is one of the best-known genetic abnormalities in hematological malignancies. Major BCR-ABL translocation is much more common in chronic myelogenous leukemia (CML) and minor BCR-ABL in acute lymphoblastic leukemia. We experienced an extraordinarily rare case of CML with an e8a2 variant. An unusual band, other than the common transcripts, was observed in reverse transcription-polymerase chain reaction (RT-PCR) for the BCR-ABL gene rearrangement. Sequence analysis of the PCR product revealed an 1172-bp e8a2 fusion with a 14-bp insertion of ABL intron Ia. The patient achieved a complete hematological response 3 months after imatinib treatment. It is necessary to keep in mind that an unexpected band revealed with RT-PCR may mean the presence of unusual fusion gene.
MeSH terms
Gene Fusion*Gene RearrangementGenes, abl*HumansIn Situ Hybridization, FluorescenceLeukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics*MaleMiddle AgedRNA, Messenger/genetics*Reverse Transcriptase Polymerase Chain Reaction
DOI
10.1016/j.cancergencyto.2008.06.001
PMID
18722880
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
AJOU Authors
박, 일중임, 영애이, 위교박, 준성김, 효철조, 성란
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse