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Dexamethasone reduces food intake, weight gain and the hypothalamic 5-HT concentration and increases plasma leptin in rats.

DC Field Value Language
dc.contributor.authorJahng, JW-
dc.contributor.authorKim, NY-
dc.contributor.authorRyu, V-
dc.contributor.authorYoo, SB-
dc.contributor.authorKim, BT-
dc.contributor.authorKang, DW-
dc.contributor.authorLee, JH-
dc.date.accessioned2011-01-12T01:47:46Z-
dc.date.available2011-01-12T01:47:46Z-
dc.date.issued2008-
dc.identifier.issn0014-2999-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1100-
dc.description.abstractThis study was conducted to define the regulatory mechanisms underlying stress-induced decreases in food intake and weight gain. Rats received a single or 4 daily injections of dexamethasone (0.1 or 1 mg/kg). Food intake and weight gain were recorded, and plasma leptin, brain contents of serotonin (5-hydroxytryptamine; 5-HT), 5-hydroxy-indole-acetic acid (5-HIAA) and the raphe expression of tryptophan hydroxylase (TPH), monoamine oxidase A (MAO-A) and 5-HT reuptake transporter (5-HTT) genes were examined. A single injection of dexamethasone did not acutely affect food intake, but cumulative food intake and weight gain were suppressed dose-dependently by daily injections of dexamethasone. Both a single and repeated injections of dexamethasone elevated plasma leptin in a dose dependent manner. 5-HT contents in the hypothalamus was decreased, but 5-HIAA increased, both by a single and repeated dexamethasone. A single injection of dexamethasone did not affect mRNA expressions of TPH, MAO-A and 5-HTT genes, but repeated dexamethasone increased them in the dorsal raphe nucleus. These results suggest that plasma leptin may play a role in dexamethasone-induced anorexia. Additionally, increased expression of MAO-A and 5-HTT genes by repeated dexamethasone appears to be implicated in decreases of the brain 5-HT contents.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHDexamethasone/pharmacology*-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHEating/drug effects*-
dc.subject.MESHHydroxyindoleacetic Acid/analysis-
dc.subject.MESHHypothalamus/chemistry*-
dc.subject.MESHLeptin/blood*-
dc.subject.MESHMale-
dc.subject.MESHMonoamine Oxidase/genetics-
dc.subject.MESHRNA, Messenger/analysis-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptors, Serotonin/physiology-
dc.subject.MESHSerotonin/analysis*-
dc.subject.MESHSerotonin Plasma Membrane Transport Proteins/genetics-
dc.subject.MESHTryptophan Hydroxylase/genetics-
dc.subject.MESHWeight Gain/drug effects*-
dc.titleDexamethasone reduces food intake, weight gain and the hypothalamic 5-HT concentration and increases plasma leptin in rats.-
dc.typeArticle-
dc.identifier.pmid18164702-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0014-2999(07)01289-7-
dc.contributor.affiliatedAuthor김, 범택-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.ejphar.2007.11.029-
dc.citation.titleEuropean journal of pharmacology-
dc.citation.volume581-
dc.citation.number1-2-
dc.citation.date2008-
dc.citation.startPage64-
dc.citation.endPage70-
dc.identifier.bibliographicCitationEuropean journal of pharmacology, 581(1-2):64-70, 2008-
dc.identifier.eissn1879-0712-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Family Practice & Community Health

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