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Dexamethasone reduces food intake, weight gain and the hypothalamic 5-HT concentration and increases plasma leptin in rats.
DC Field | Value | Language |
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dc.contributor.author | Jahng, JW | - |
dc.contributor.author | Kim, NY | - |
dc.contributor.author | Ryu, V | - |
dc.contributor.author | Yoo, SB | - |
dc.contributor.author | Kim, BT | - |
dc.contributor.author | Kang, DW | - |
dc.contributor.author | Lee, JH | - |
dc.date.accessioned | 2011-01-12T01:47:46Z | - |
dc.date.available | 2011-01-12T01:47:46Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/1100 | - |
dc.description.abstract | This study was conducted to define the regulatory mechanisms underlying stress-induced decreases in food intake and weight gain. Rats received a single or 4 daily injections of dexamethasone (0.1 or 1 mg/kg). Food intake and weight gain were recorded, and plasma leptin, brain contents of serotonin (5-hydroxytryptamine; 5-HT), 5-hydroxy-indole-acetic acid (5-HIAA) and the raphe expression of tryptophan hydroxylase (TPH), monoamine oxidase A (MAO-A) and 5-HT reuptake transporter (5-HTT) genes were examined. A single injection of dexamethasone did not acutely affect food intake, but cumulative food intake and weight gain were suppressed dose-dependently by daily injections of dexamethasone. Both a single and repeated injections of dexamethasone elevated plasma leptin in a dose dependent manner. 5-HT contents in the hypothalamus was decreased, but 5-HIAA increased, both by a single and repeated dexamethasone. A single injection of dexamethasone did not affect mRNA expressions of TPH, MAO-A and 5-HTT genes, but repeated dexamethasone increased them in the dorsal raphe nucleus. These results suggest that plasma leptin may play a role in dexamethasone-induced anorexia. Additionally, increased expression of MAO-A and 5-HTT genes by repeated dexamethasone appears to be implicated in decreases of the brain 5-HT contents. | - |
dc.language.iso | en | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Dexamethasone | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Eating | - |
dc.subject.MESH | Hydroxyindoleacetic Acid | - |
dc.subject.MESH | Hypothalamus | - |
dc.subject.MESH | Leptin | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Monoamine Oxidase | - |
dc.subject.MESH | RNA, Messenger | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptors, Serotonin | - |
dc.subject.MESH | Serotonin | - |
dc.subject.MESH | Serotonin Plasma Membrane Transport Proteins | - |
dc.subject.MESH | Tryptophan Hydroxylase | - |
dc.subject.MESH | Weight Gain | - |
dc.title | Dexamethasone reduces food intake, weight gain and the hypothalamic 5-HT concentration and increases plasma leptin in rats. | - |
dc.type | Article | - |
dc.identifier.pmid | 18164702 | - |
dc.identifier.url | http://linkinghub.elsevier.com/retrieve/pii/S0014-2999(07)01289-7 | - |
dc.contributor.affiliatedAuthor | 김, 범택 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.ejphar.2007.11.029 | - |
dc.citation.title | European journal of pharmacology | - |
dc.citation.volume | 581 | - |
dc.citation.number | 1-2 | - |
dc.citation.date | 2008 | - |
dc.citation.startPage | 64 | - |
dc.citation.endPage | 70 | - |
dc.identifier.bibliographicCitation | European journal of pharmacology, 581(1-2). : 64-70, 2008 | - |
dc.identifier.eissn | 1879-0712 | - |
dc.relation.journalid | J000142999 | - |
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