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Misclassification of cases by querying modality: comparison of ICD-10 codes with clinical laboratory test results

Cho, Soo Yeon; Ahn, Eun Kyoung; Park, Rae Woong
Department of Biomedical Informatics, Ajou University School of Medicine
Misclassification is an important bias in observational studies using electronic health records. This study compared case enrollment by two querying modalities: diagnostic codes and laboratory test results. In total, 7,385 cases of chronic renal failure were enrolled by diagnosis and 17,643 by laboratory test results. The number of enrolled cases was significantly different by querying modalities. In the intersection group (n=4,211), mean difference in the start of observation was significant between the two modalities (711±871 days). The querying modality should be carefully considered and evaluated.
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