Predictors of asthma control by stepwise treatment in elderly asthmatic patients
Ban, Ga-Young; Ye, Young-Min; Lee, Yunhwan; Kim, Jeong-Eun; Nam, Young-Hee; Lee, Soo-Keol; Kim, Joo-Hee; Jung, Ki-Suck; Kim, Sang-Ha; Park, Hae-Sim
Department of Allergy & Clinical Immunology, Ajou University School of Medicine
RATIONALE: The geriatric population is increasing and asthma severity increases with age.
METHODS: We determined the predictors for asthma control and exacerbation in elderly Korean patients with asthma. In addition, we investigated the factors that affect asthma-specific quality of life (A-QOL). This is a prospective, multi-center real-life study for 6 months with stepwise pharmacologic treatment. A total of 296 asthmatic patients aged ≥ 60 were recruited from five University Centers in Korea. Improved-asthma-control group was defined if patients maintained well controlled status or improved control status for 6 months; the remaining patients were defined as not-improved-asthma-control group.
RESULTS: Smaller number of medications for co-morbidities and higher physical functioning (PF) scale were significant predictors for the improved asthma control group (OR = 0.863, P = 0.004; OR = 1.028, P = 0.018, respectively). Asthma control test (ACT) score ≤19 at baseline was a significant predictor of asthma exacerbation at 6 months (OR = 3.938, P = 0.048). Asthma duration (F = 5.656, P=0.018), ACT (F = 12.237, P=0.001) at baseline and the presence of asthma exacerbation (F = 5.565, P=0.019) during the 6 months of treatment were significant determinants for the changes of A-QOL.
CONCLUSIONS: The number of medications for co-morbidities and performance status determined by PF scale as well as ACT are important parameters for assessing asthma control in elderly asthma patients.
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