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Hydrogen peroxide induces hyphal differentiation in Candida albicans.

Authors
Nasution, O; Srinivasa, K; Kim, M; Kim, YJ; Kim, W; Jeong, W; Choi, W
Citation
Eukaryotic cell, 7(11):2008-2011, 2008
Journal Title
Eukaryotic cell
ISSN
1535-97781535-9786
Abstract
In this study, we demonstrate that hyphal differentiation is induced by the subtoxic concentration of exogenous H(2)O(2) in Candida albicans. This finding is confirmed by the changing intracellular concentration of H(2)O(2). In order to induce the same level of differentiation, low concentrations of exogenous H(2)O(2) are required for the null mutants of the thiol-specific antioxidant and catalase, while higher concentrations are needed for cells treated with ascorbic acid, an antioxidant chemical.
MeSH terms
Ascorbic Acid/metabolismCandida albicans/cytologyCandida albicans/geneticsCandida albicans/physiology*Hydrogen Peroxide/metabolism*Hyphae/cytologyHyphae/geneticsHyphae/physiology*
DOI
10.1128/EC.00105-08
PMID
18791036
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
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