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CD4+CD25+ regulatory T cells selectively diminish systemic autoreactivity in arthritic K/BxN mice.

Kang, SM; Jang, E; Paik, DJ; Jang, YJ; Youn, J
Molecules and cells, 25(1):64-69, 2008
Journal Title
Molecules and cells
Although the arthritis symptoms observed in the K/BxN model have been shown to be dependent on the functions of T and B cells specific to the self antigen glucose-6-phosphate isomerase, less is known about the in vivo roles of CD4(+)CD25(+) regulatory T (T(reg)) cells in the pathology of K/BxN mice. We determined the quantitative and functional characteristics of the T(reg) cells in K/BxN mice. These mice contained a higher percentage of Foxp3(+) T(reg) cells among the CD4(+) T cells than their BxN littermates. These T(reg) cells were anergic and efficiently suppressed the proliferation of naïve CD4(+) T cells and cytokine production by effector CD4(+) T cells in vitro. Antibody-mediated depletion of CD25(+) cells caused K/BxN mice to develop multi-organ inflammation and autoantibody production, while the symptoms of arthritis were not affected. These results demonstrate that despite the inability of the T(reg) cells to suppress arthritis development, they play a critical role protecting the arthritic mice from systemic expansion of autoimmunity.
MeSH terms
AnimalsArthritis, Experimental/immunology*Autoantibodies/metabolismAutoimmunity/immunology*CD4-Positive T-Lymphocytes/immunology*HumansInflammation/immunologyInterleukin-2 Receptor alpha Subunit/immunology*vLymphocyte ActivationLymphoid Tissue/cytologyLymphoid Tissue/immunologyMiceMice, Inbred C57BLMice, Inbred NODMice, Inbred StrainsMice, TransgenicT-Lymphocyte Subsets/immunology*T-Lymphocytes, Regulatory/immunology*
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
AJOU Authors
장, 영주
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