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Prefrontal cortex and hippocampus subserve different components of working memory in rats.

Authors
Yoon, T; Okada, J; Jung, MW; Kim, JJ
Citation
Learning & memory (Cold Spring Harbor, N.Y.), 15(3):97-105, 2008
Journal Title
Learning & memory (Cold Spring Harbor, N.Y.)
ISSN
1072-05021549-5485
Abstract
Both the medial prefrontal cortex (mPFC) and hippocampus are implicated in working memory tasks in rodents. Specifically, it has been hypothesized that the mPFC is primarily engaged in the temporary storage and processing of information lasting from a subsecond to several seconds, while the hippocampal function becomes more critical as the working memory demand extends into longer temporal scales. Although these structures may be engaged in a temporally separable manner, the extent of their contributions in the "informational content" of working memory remains unclear. To investigate this issue, the mPFC and dorsal hippocampus (dHPC) were temporarily inactivated via targeted infusions of the GABA(A) receptor agonist muscimol in rats prior to their performance on a delayed alternation task (DAT), employing an automated figure-eight maze that required the animals to make alternating arm choice responses after 3-, 30-, and 60-sec delays for water reward. We report that inactivation of either the mPFC or dHPC significantly reduced DAT at all delay intervals tested. However, there were key qualitative differences in the behavioral effects. Specifically, mPFC inactivation selectively impaired working memory (i.e., arm choice accuracy) without altering reference memory (i.e., the maze task rule) and arm choice response latencies. In contrast, dHPC inactivation increased both reference memory errors and arm choice response latencies. Moreover, dHPC, but not mPFC, inactivation increased the incidence of successive working memory errors. These results suggest that while both the mPFC and hippocampus are necessarily involved in DAT, they seem to process different informational components associated with the memory task.
MeSH terms
AnimalsBrain MappingChoice Behavior/drug effectsChoice Behavior/physiologyGABA Agonists/administration & dosageGABA Agonists/pharmacologyHippocampus/drug effectsHippocampus/physiology*InjectionsMaleMaze Learning/drug effectsMaze Learning/physiologyMemory/drug effectsMemory/physiology*Muscimol/administration & dosageMuscimol/pharmacologyPrefrontal Cortex/physiology*RatsRats, Sprague-DawleyReaction Time/drug effectsvReaction Time/physiology
DOI
10.1101/lm.850808
PMID
18285468
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
AJOU Authors
정민환
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