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Expression of cytokines and cytokine receptors in human Schwann cells.

Authors
Ozaki, A; Nagai, A; Lee, YB; Myong, NH; Kim, SU
Citation
Neuroreport, 19(1):31-35, 2008
Journal Title
Neuroreport
ISSN
0959-49651473-558X
Abstract
The expression of cytokines and cytokine receptors was investigated in enriched populations of human fetal Schwann cells by reverse transcribed-PCR and enzyme-linked immunosorbent assay. Human fetal Schwann cells constitutively expressed mRNA of IL-1beta, IL-6, IL-8, IL-11, IL-12, IL-15 and TGF-beta, and also cytokine receptors for IL-1, IL-4, IL-6, IL-8, IL-13, tissue necrosis factor and gp130. The expression of IL-1beta, IL-6 and IL-15 was upregulated following treatment with IL-1beta or TGF-beta. The protein levels of IL-6 were increased with IL-1beta treatment, but were decreased with IFN-gamma treatment. Human Schwann cells may respond to cytokine signals in the nerve injury sites and modify the pathological conditions by secreting cytokines. The secreted cytokines may play a role in leukocyte recruitment and exacerbation of axonal injury process.
MeSH terms
Cells, CulturedCytokines/geneticsCytokines/metabolism*Cytokines/pharmacologyEnzyme-Linked Immunosorbent Assay/methodsGanglia, Spinal/cytologyHumansRNA, Messenger/metabolismReceptors, Cytokine/geneticsReceptors, Cytokine/metabolism*Reverse Transcriptase Polymerase Chain Reaction/methodsSchwann Cells/metabolism*Up-Regulation/drug effectsUp-Regulation/physiology
DOI
10.1097/WNR.0b013e3282f27e60
PMID
18281888
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
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