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Glucose Lowering Effect of SGLT2 Inhibitors: A Review of Clinical Studies

Other Title
SGLT2 억제제의 혈당 강하 효과
Authors
Kim, HJ
Citation
The Journal of Korean Diabetes, 15(3). : 146-150, 2014
Journal Title
The Journal of Korean Diabetes
ISSN
2233-7431
Abstract
There are numerous glucose lowering agents in clinical use for type 2 diabetic patients, yet most do not achieve glycemic targets. Recently, inhibitors of the sodium glucose cotransporter 2 (SGLT2) have been developed, which show great potential of being a novel therapeutic option to treat type 2 diabetes. Many researches have turned their attention to the kidney as a target because renal glucose reabsorption is increased in type 2 DM. SGLT2 is a protein transporter that mediates glucose reabsorption from glomerular filtrates. In an insulinindependent manner, inhibition of SGLT2 increases urinary glucose excretion and decreases plasma glucose levels. To date, there are a few SGLT2 inhibiting agents being clinically studied both as a monotherapy and in combination with other antidiabetic agents. This review will focus on the efficacy of SGLT2 inhibitors based on clinical studies.
Keywords
DOI
10.4093/jkd.2014.15.3.146
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
Ajou Authors
김, 혜진
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