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In Thyroid Cancer Patients, Is Preoperative FNAB-C Reliable for Prediction of Lateral Cervical LN Metastasis?

Other Title
갑상선암 환자에서 측경부 림프절 전이여부 진단에 세침흡인세포검사가 믿을만한가?
Authors
서, 수한 | 이, 정훈  | 소, 의영
Citation
Korean Journal of Endocrine Surgery, 14(2). : 76-80, 2014
Journal Title
Korean Journal of Endocrine Surgery
ISSN
1598-17032287-6782
Abstract
Purpose: The goal of this study was to evaluate the diagnostic accuracy of preoperative fine needle aspiration biopsy cytology (FNAB-C) in predicting lateral lymph node metastasis in papillary thyroid cancer patients.Methods: A total of 592 patients who underwent thyroid cancer surgery and intra- operative lateral cervical LN frozen section or RND, from January 2002 to December 2011, were evaluated retrospectively. Among them, 228 cases had suspicious findings in FNAB-C of lateral nodes. We reviewed their radiological and pathological reports.Results: Intra-operative frozen section examination was performed in 540 cases and RND was performed in 314 cases. This study included 534 women (83.4%) and 106 men (16.6%). Patients’ ranged in age from 9 to 83 years (mean, 45.65 years). FNAB-C was per-formed in 228 cases. The sensitivity and specificity of FNAB-C was 71.5% and 78.6%, respectively; 35.9% of cases had a false negative result. The combination of FNAB-C and intra-operative frozen section test sensitivity and specificity was 87.2% and 93.6%, respectively.Conclusion: The results for sensitivity in FNAB-C actually appear low, and false negative results were very high. In papillary thyroid cancer in patients with FNAB-C, even if the result is negative, if lymph node metastasis is suspected based on radiologic evidence, frozen section examination should be performed for determination of metastasis.
Keywords

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Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Ajou Authors
소, 의영  |  이, 정훈
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