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Dissociated Antidepressant and Analgesic Effects of Intravenous Ketamine in Patients with Chronic Pain

Other Title
만성 통증 환자를 통한 케타민 정맥 투여의 진통 효과와 구분되는 항우울 효과 연구
Authors
박, 지웅; 김, 도완; 신, 경민; 노, 재성
Citation
Taehan Chŏngsin Yangmul Hakhoe chi, 25(4):192-199, 2014
Journal Title
Taehan Chŏngsin Yangmul Hakhoe chi; The Korean journal of psychopharmacology; 대한정신약물학회지
ISSN
1017-57172092-5700
Abstract
Objective: Recent studies about low-dose ketamine therapy have found significant improvement of depressive symptoms within a few hours or days. This study was designed to investigate the effect of ketamine on mood in patients with chronic pain.



Methods: Forty subjects with chronic pain were recruited from the pain clinic of the Ajou University Hospital. The Beck Depression Inventory was used to evaluate mood in each patient, and then the patients received ketamine hydrochloride (1.2 mg/kg, average) intravenously over the course of 1 hour. Visual Analogue Scale (VAS) for depression, anxiety, and pain were completed by the subjects just before and 3 hours after ketamine infusion.



Results: VAS scores for depression, anxiety, and pain were significantly decreased after ketamine infusion. VAS for depression, anxiety, and pain showed significant correlation with each other before ketamine infusion; however, correlations of the VAS scores for pain with the other two visual scale measures were absent at post-ketamine administration while the correlation between depression and anxiety following ketamine infusion was maintained.

Conclusion: To our knowledge, this is the first report about the antidepressant effect of intravenous ketamine, which is separated from its analgesic effect in patients with chronic pain. This result raises the possibility that the antidepressant effect of ketamine is generated by a mechanism different from that of the analgesic effect in human.
Keywords
WordszzKetamineNMDA antagonistAntidepressant effectDepressionChronic pain
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
AJOU Authors
김, 도완신, 경민노, 재성
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