31 318

Cited 28 times in

Ginseng, the root of Panax ginseng C.A. Meyer, protects ethanol-induced gastric damages in rat through the induction of cytoprotective heat-shock protein 27.

Authors
Yeo, M; Kim, DK; Cho, SW; Hong, HD
Citation
Digestive diseases and sciences, 53(3):606-613, 2008
Journal Title
Digestive diseases and sciences
ISSN
0163-21161573-2568
Abstract
Ginseng, the root of Panax ginseng C.A. Meyer, has been reported to exert preventive effects on gastropathy via anti-oxidative and anti-inflammatory actions. In this study, we investigated the protective effects of ginseng against ethanol-induced gastric damages in rat. To examine the preventive effect of ginseng, rats received two different ginseng extracts, A and B, 1 h prior to the administration of ethanol. Pretreatment of rats with ginseng extract A and B attenuated the ethanol-induced gastric lesions by 111 +/- 48 and 142 +/- 47 mm(2) compared to control group (164 +/- 54 mm(2)). Significant induction of cytoprotective heat-shock proteins HSP27 and HSP70 was found in the ginseng-administrated rats, suggesting that the restoration of the proteins might contribute to prevention of ethanol-induced gastric injuries. It is, therefore, suggested that ginseng has a protective effect against ethanol-induced gastric damages by induction of heat-shock proteins 70 and 27.
MeSH terms
AnimalsCell Death/drug effectsCyclooxygenase 2/metabolismCytoprotectionEthanol/adverse effectsGastric Mucosa/drug effectsHSP70 Heat-Shock Proteins/metabolismHeat-Shock Proteins/metabolism*MalePanax*Phytotherapy*Plant Extracts/pharmacologyPlant Extracts/therapeutic use*Plant RootsRatsRats, Sprague-DawleyStomach Ulcer/chemically inducedStomach Ulcer/prevention & control*
DOI
10.1007/s10620-007-9946-6
PMID
17763949
Appears in Collections:
Journal Papers > Research Organization > Genomic Research Center for Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
여말희조성원
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse