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Ginseng, the root of Panax ginseng C.A. Meyer, protects ethanol-induced gastric damages in rat through the induction of cytoprotective heat-shock protein 27.

Yeo, M; Kim, DK; Cho, SW; Hong, HD
Digestive diseases and sciences, 53(3):606-613, 2008
Journal Title
Digestive diseases and sciences
Ginseng, the root of Panax ginseng C.A. Meyer, has been reported to exert preventive effects on gastropathy via anti-oxidative and anti-inflammatory actions. In this study, we investigated the protective effects of ginseng against ethanol-induced gastric damages in rat. To examine the preventive effect of ginseng, rats received two different ginseng extracts, A and B, 1 h prior to the administration of ethanol. Pretreatment of rats with ginseng extract A and B attenuated the ethanol-induced gastric lesions by 111 +/- 48 and 142 +/- 47 mm(2) compared to control group (164 +/- 54 mm(2)). Significant induction of cytoprotective heat-shock proteins HSP27 and HSP70 was found in the ginseng-administrated rats, suggesting that the restoration of the proteins might contribute to prevention of ethanol-induced gastric injuries. It is, therefore, suggested that ginseng has a protective effect against ethanol-induced gastric damages by induction of heat-shock proteins 70 and 27.
MeSH terms
AnimalsCell Death/drug effectsCyclooxygenase 2/metabolismCytoprotectionEthanol/adverse effectsGastric Mucosa/drug effectsHSP70 Heat-Shock Proteins/metabolismHeat-Shock Proteins/metabolism*MalePanax*Phytotherapy*Plant Extracts/pharmacologyPlant Extracts/therapeutic use*Plant RootsRatsRats, Sprague-DawleyStomach Ulcer/chemically inducedStomach Ulcer/prevention & control*
Appears in Collections:
Journal Papers > Research Organization > Genomic Research Center for Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
여, 말희조, 성원
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